Serum iron and plasma fibrinogen concentrations as indicators of systemic inflammatory diseases in horses
dc.contributor.author | Borges, Alexandre S. [UNESP] | |
dc.contributor.author | Divers, Thomas J. [UNESP] | |
dc.contributor.author | Stokol, Tracy [UNESP] | |
dc.contributor.author | Mohammed, O. Hussni [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.date.accessioned | 2022-04-28T20:17:20Z | |
dc.date.available | 2022-04-28T20:17:20Z | |
dc.date.issued | 2007-05-01 | |
dc.description.abstract | Background: Detection of systemic inflammation, which is important for proper diagnosis and prompt treatment, can be challenging. Hypothesis: Measurement of plasma iron concentration is a sensitive method for detecting systemic inflammation in horses compared with measurements of plasma fibrinogen concentration, a traditional marker for inflammation in the horse. Animals: Ninety-seven horses hospitalized with diseases causing systemic inflammation, 22 horses with localized inflammation, and 12 clinically normal horses were included in this study. Methods: A retrospective study was made on hospitalized horses that had both plasma iron and fibrinogen concentrations measured on hospital admission. Results: Plasma iron concentration was lower in horses with systemic inflammation (64 ± 45 μg/dL) than the reference interval minimum (105 μg/dL) and were significantly lower (P = .001) than the value in a group of horses with local inflammation (123 ± 45 μg/dL) and in healthy transported horses (143 ± 29 μg/dL). Low plasma iron and high fibrinogen concentrations were both sensitive indicators of systemic inflammation in horses with sensitivity of 90 and 82%, respectively. There was a similar correlation between either continued decreases in iron concentration (Rsp of 0.239) or increases in fibrinogen concentration (R sp of 0.280) during hospitalization and a worse prognosis. Conclusions and Clinical Importance: Measurement of plasma iron concentration better reflected acute inflammation than did fibrinogen concentration. Copyright © 2007 by the American College of Veterinary Internal Medicine. | en |
dc.description.affiliation | Department of Veterinary Clinical Science Sao Paulo State University FMVZ Botucatu SP | |
dc.description.affiliation | Department of Veterinary Clinical Science Sao Paulo State University FMVZ, Botucatu SP, 18618000 | |
dc.description.affiliationUnesp | Department of Veterinary Clinical Science Sao Paulo State University FMVZ Botucatu SP | |
dc.description.affiliationUnesp | Department of Veterinary Clinical Science Sao Paulo State University FMVZ, Botucatu SP, 18618000 | |
dc.format.extent | 489-494 | |
dc.identifier | http://dx.doi.org/10.1892/0891-6640(2007)21[489:SIAPFC]2.0.CO;2 | |
dc.identifier.citation | Journal of Veterinary Internal Medicine, v. 21, n. 3, p. 489-494, 2007. | |
dc.identifier.doi | 10.1892/0891-6640(2007)21[489:SIAPFC]2.0.CO;2 | |
dc.identifier.issn | 0891-6640 | |
dc.identifier.scopus | 2-s2.0-34249295167 | |
dc.identifier.uri | http://hdl.handle.net/11449/224909 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Veterinary Internal Medicine | |
dc.source | Scopus | |
dc.subject | Acute phase reactant protein | |
dc.subject | Horse | |
dc.subject | Inflammation | |
dc.title | Serum iron and plasma fibrinogen concentrations as indicators of systemic inflammatory diseases in horses | en |
dc.type | Artigo |