Serum iron and plasma fibrinogen concentrations as indicators of systemic inflammatory diseases in horses

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dc.contributor.authorBorges, Alexandre S. [UNESP]
dc.contributor.authorDivers, Thomas J. [UNESP]
dc.contributor.authorStokol, Tracy [UNESP]
dc.contributor.authorMohammed, O. Hussni [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T20:17:20Z
dc.date.available2022-04-28T20:17:20Z
dc.date.issued2007-05-01
dc.description.abstractBackground: Detection of systemic inflammation, which is important for proper diagnosis and prompt treatment, can be challenging. Hypothesis: Measurement of plasma iron concentration is a sensitive method for detecting systemic inflammation in horses compared with measurements of plasma fibrinogen concentration, a traditional marker for inflammation in the horse. Animals: Ninety-seven horses hospitalized with diseases causing systemic inflammation, 22 horses with localized inflammation, and 12 clinically normal horses were included in this study. Methods: A retrospective study was made on hospitalized horses that had both plasma iron and fibrinogen concentrations measured on hospital admission. Results: Plasma iron concentration was lower in horses with systemic inflammation (64 ± 45 μg/dL) than the reference interval minimum (105 μg/dL) and were significantly lower (P = .001) than the value in a group of horses with local inflammation (123 ± 45 μg/dL) and in healthy transported horses (143 ± 29 μg/dL). Low plasma iron and high fibrinogen concentrations were both sensitive indicators of systemic inflammation in horses with sensitivity of 90 and 82%, respectively. There was a similar correlation between either continued decreases in iron concentration (Rsp of 0.239) or increases in fibrinogen concentration (R sp of 0.280) during hospitalization and a worse prognosis. Conclusions and Clinical Importance: Measurement of plasma iron concentration better reflected acute inflammation than did fibrinogen concentration. Copyright © 2007 by the American College of Veterinary Internal Medicine.en
dc.description.affiliationDepartment of Veterinary Clinical Science Sao Paulo State University FMVZ Botucatu SP
dc.description.affiliationDepartment of Veterinary Clinical Science Sao Paulo State University FMVZ, Botucatu SP, 18618000
dc.description.affiliationUnespDepartment of Veterinary Clinical Science Sao Paulo State University FMVZ Botucatu SP
dc.description.affiliationUnespDepartment of Veterinary Clinical Science Sao Paulo State University FMVZ, Botucatu SP, 18618000
dc.format.extent489-494
dc.identifierhttp://dx.doi.org/10.1892/0891-6640(2007)21[489:SIAPFC]2.0.CO;2
dc.identifier.citationJournal of Veterinary Internal Medicine, v. 21, n. 3, p. 489-494, 2007.
dc.identifier.doi10.1892/0891-6640(2007)21[489:SIAPFC]2.0.CO;2
dc.identifier.issn0891-6640
dc.identifier.scopus2-s2.0-34249295167
dc.identifier.urihttp://hdl.handle.net/11449/224909
dc.language.isoeng
dc.relation.ispartofJournal of Veterinary Internal Medicine
dc.sourceScopus
dc.subjectAcute phase reactant protein
dc.subjectHorse
dc.subjectInflammation
dc.titleSerum iron and plasma fibrinogen concentrations as indicators of systemic inflammatory diseases in horsesen
dc.typeArtigo

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