Mapping MHC genes in river buffalo
dc.contributor.author | Rodrigues Filho, E. A. [UNESP] | |
dc.contributor.author | Stafuzza, N. B. [UNESP] | |
dc.contributor.author | Caetano, A. R. | |
dc.contributor.author | Gill, C. A. | |
dc.contributor.author | Riggs, P. K. | |
dc.contributor.author | Womack, J. E. | |
dc.contributor.author | Amaral, M. E.J. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) | |
dc.contributor.institution | Texas A and M University | |
dc.contributor.institution | BLDG. | |
dc.date.accessioned | 2022-04-28T20:43:56Z | |
dc.date.available | 2022-04-28T20:43:56Z | |
dc.date.issued | 2008-01-01 | |
dc.description.abstract | The major histocompatibility complex (MHC) contains a set of genes necessary for antigen presentation in the immune system. This gene dense and polymorphic region of the mammalian genome is of considerable interest due to the role of MHC genes in immune function and animal health. Previous cytogenetic studies have indicated that the MHC in river buffalo resides on the short arm of chromosome 2 (BBU2). A 5000-rad radiation hybrid mapping panel was recently generated to enable construction of a whole genome map of river buffalo. To this end, the aims of this project were to elucidate the general organization of the MHC on BBU2, and to compare gene order within this region to the MHC in cattle. PCR primers were selected from the bovine gene map and used with the BBURH 5000 panel to map a set often MHC class II genes in river buffalo. Analysis indicates that these genes fall into two linkage groups, consistent with organization of the MHC in cattle. This comparison of buffalo and bovine MHC gene order provides the first insight into the organization of the MHC on river buffalo chromosome 2. | en |
dc.description.affiliation | UNESP São Paulo State University IBILCE Depto. Biologia, São Jose Rio Preto | |
dc.description.affiliation | Embrapa Recursos Genéticos e Biotecnologia, Brasília, DF | |
dc.description.affiliation | Department of Animal Science Texas A and M University, College Station, TX | |
dc.description.affiliation | Department of Veterinary Pathobiology Texas A and M University, College Station, TX | |
dc.description.affiliation | Department of Veterinary Pathobiology Texas A and M University Vet. Med. Res. BLDG., 1197, Raymond Stotzer Parkway, College Station, TX 77843-4467 | |
dc.description.affiliationUnesp | UNESP São Paulo State University IBILCE Depto. Biologia, São Jose Rio Preto | |
dc.format.extent | 343-346 | |
dc.identifier | http://dx.doi.org/10.1159/000317181 | |
dc.identifier.citation | Developments in Biologicals, v. 132, p. 343-346. | |
dc.identifier.doi | 10.1159/000317181 | |
dc.identifier.issn | 1424-6074 | |
dc.identifier.scopus | 2-s2.0-50249154029 | |
dc.identifier.uri | http://hdl.handle.net/11449/225257 | |
dc.language.iso | eng | |
dc.relation.ispartof | Developments in Biologicals | |
dc.source | Scopus | |
dc.subject | BBU2p | |
dc.subject | MHC genes | |
dc.subject | RH mapping | |
dc.subject | River buffalo | |
dc.title | Mapping MHC genes in river buffalo | en |
dc.type | Trabalho apresentado em evento | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto | pt |
unesp.department | Biologia - IBILCE | pt |