Mapping MHC genes in river buffalo

dc.contributor.authorRodrigues Filho, E. A. [UNESP]
dc.contributor.authorStafuzza, N. B. [UNESP]
dc.contributor.authorCaetano, A. R.
dc.contributor.authorGill, C. A.
dc.contributor.authorRiggs, P. K.
dc.contributor.authorWomack, J. E.
dc.contributor.authorAmaral, M. E.J. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionTexas A and M University
dc.contributor.institutionBLDG.
dc.date.accessioned2022-04-28T20:43:56Z
dc.date.available2022-04-28T20:43:56Z
dc.date.issued2008-01-01
dc.description.abstractThe major histocompatibility complex (MHC) contains a set of genes necessary for antigen presentation in the immune system. This gene dense and polymorphic region of the mammalian genome is of considerable interest due to the role of MHC genes in immune function and animal health. Previous cytogenetic studies have indicated that the MHC in river buffalo resides on the short arm of chromosome 2 (BBU2). A 5000-rad radiation hybrid mapping panel was recently generated to enable construction of a whole genome map of river buffalo. To this end, the aims of this project were to elucidate the general organization of the MHC on BBU2, and to compare gene order within this region to the MHC in cattle. PCR primers were selected from the bovine gene map and used with the BBURH 5000 panel to map a set often MHC class II genes in river buffalo. Analysis indicates that these genes fall into two linkage groups, consistent with organization of the MHC in cattle. This comparison of buffalo and bovine MHC gene order provides the first insight into the organization of the MHC on river buffalo chromosome 2.en
dc.description.affiliationUNESP São Paulo State University IBILCE Depto. Biologia, São Jose Rio Preto
dc.description.affiliationEmbrapa Recursos Genéticos e Biotecnologia, Brasília, DF
dc.description.affiliationDepartment of Animal Science Texas A and M University, College Station, TX
dc.description.affiliationDepartment of Veterinary Pathobiology Texas A and M University, College Station, TX
dc.description.affiliationDepartment of Veterinary Pathobiology Texas A and M University Vet. Med. Res. BLDG., 1197, Raymond Stotzer Parkway, College Station, TX 77843-4467
dc.description.affiliationUnespUNESP São Paulo State University IBILCE Depto. Biologia, São Jose Rio Preto
dc.format.extent343-346
dc.identifierhttp://dx.doi.org/10.1159/000317181
dc.identifier.citationDevelopments in Biologicals, v. 132, p. 343-346.
dc.identifier.doi10.1159/000317181
dc.identifier.issn1424-6074
dc.identifier.scopus2-s2.0-50249154029
dc.identifier.urihttp://hdl.handle.net/11449/225257
dc.language.isoeng
dc.relation.ispartofDevelopments in Biologicals
dc.sourceScopus
dc.subjectBBU2p
dc.subjectMHC genes
dc.subjectRH mapping
dc.subjectRiver buffalo
dc.titleMapping MHC genes in river buffaloen
dc.typeTrabalho apresentado em evento
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia - IBILCEpt

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