Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery

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dc.contributor.authorRiccio, Bruno Vincenzo Fiod [UNESP]
dc.contributor.authorKlosowski, Ana Beatriz
dc.contributor.authorPrestes, Eduardo
dc.contributor.authorde Sousa, Taynara Barbosa
dc.contributor.authorde Assunção Morais, Laís Caroline
dc.contributor.authorLemes, Bruna Mikulis
dc.contributor.authorBeltrame, Flávio Luís
dc.contributor.authorCampos, Patrícia Mazureki
dc.contributor.authorFerrari, Priscileila Colerato
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Ponta Grossa (UEPG)
dc.date.accessioned2021-06-25T10:22:07Z
dc.date.available2021-06-25T10:22:07Z
dc.date.issued2021-06-05
dc.description.abstractBionanocomposite films based on chitosan and nanocellulose (nanocrystals or nanofibrils) have gained considerable attention for biomedical applications, especially for wound dressings. However, the development of these films as controlled drug release dressings is still under-exploited. Therefore, this work aimed to design chitosan/nanocellulose-based bionanocomposite films, loaded by betamethasone or silver sulfadiazine, as functional dressings. The films were obtained by solvent casting and characterized by physicochemical, mechanical, barrier properties, in vitro drug release, and antimicrobial activity. The nanocellulose type, physical state, and content caused influence on the film's properties providing different physical, barrier, and drug release profiles. They are semi-occlusive and mechanically resistant; the drug release is controlled, and possesses antimicrobial activity. In conclusion, the developed biodegradable bionanocomposite films are promising as active dressings for controlled drug delivery in the wound site and have specific applications according to their features to treat inflamed and purulent wounds, non-infectious dry wounds, and infectious wounds.en
dc.description.affiliationDepartment of Pharmaceutical Sciences State University of São Paulo – UNESP
dc.description.affiliationDepartment of Pharmaceutical Sciences State University of Ponta Grossa – UEPG
dc.description.affiliationDepartment of Materials Engineering State University of Ponta Grossa – UEPG
dc.description.affiliationUnespDepartment of Pharmaceutical Sciences State University of São Paulo – UNESP
dc.identifierhttp://dx.doi.org/10.1002/app.50468
dc.identifier.citationJournal of Applied Polymer Science, v. 138, n. 21, 2021.
dc.identifier.doi10.1002/app.50468
dc.identifier.issn1097-4628
dc.identifier.issn0021-8995
dc.identifier.scopus2-s2.0-85100377139
dc.identifier.urihttp://hdl.handle.net/11449/205836
dc.language.isoeng
dc.relation.ispartofJournal of Applied Polymer Science
dc.sourceScopus
dc.subjectbiodegradable
dc.subjectbiomedical applications
dc.subjectdrug delivery systems
dc.titleChitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine deliveryen
dc.typeArtigo
unesp.author.orcid0000-0002-2370-0662[1]
unesp.author.orcid0000-0002-3189-2545[2]
unesp.author.orcid0000-0002-7104-2123[6]
unesp.author.orcid0000-0001-7067-5802[7]
unesp.author.orcid0000-0003-2659-8023[8]
unesp.author.orcid0000-0002-4285-6646[9]

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