Electrochemical sensor highly selective for estradiol valerate determination based on a modified carbon paste with iron tetrapyridinoporphyrazine

Nenhuma Miniatura disponível




Batista, Isabelle V.
Lanz, Marcos R. V.
Dias, Iara L. T.
Tanaka, Sonia M. C. N.
Tanaka, Auro A.
Sotomayor, Maria Del Pilar Taboada [UNESP]

Título da Revista

ISSN da Revista

Título de Volume


Royal Soc Chemistry


This work reports the use of iron tetrapyridinoporphyrazine (FeTPyPz) as a highly selective catalyst in the construction of an electrochemical sensor for estradiol valerate (EV) determination. The sensor was prepared by modifying a carbon paste with FeTPyPz. The best results were obtained in a mixture of acetonitrile (MeCN) and 0.1 mol L(-1) phosphate buffer solution (pH 6.0) in a volume ratio of 47 : 53. A linear response range was observed between 45 and 450 mmol L(-1) with a sensitivity of 12160 +/- 306 mu A L mol(-1) and quantification and detection limits of 45 and 13 mmol L(-1), respectively. The repeatability, expressed as the relative standard deviation (RSD) for n = 10, was 5.9% ([EV] = 50 mu mol(-1)). The reproducibility (RSD) for the sensor construction was better than 4% and the operational stability (RSD) over 50 measurements was 1.8%. A detailed investigation regarding the selectivity and electrochemical characteristics was carried out. Finally, in a first step to evaluate the application potential of the sensor, it was successfully applied to determine EV in a commercial formulation.



Como citar

Analyst. Cambridge: Royal Soc Chemistry, v. 133, n. 12, p. 1692-1699, 2008.