Ultrasonography methods for predicting malignancy in canine mammary tumors

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dc.contributor.authorFeliciano, Marcus Antonio Rossi [UNESP]
dc.contributor.authorUscategui, Ricardo Andrés Ramirez [UNESP]
dc.contributor.authorMaronezi, Marjury Cristina [UNESP]
dc.contributor.authorSimões, Ana Paula Rodrigues [UNESP]
dc.contributor.authorSilva, Priscila [UNESP]
dc.contributor.authorGasser, Beatriz [UNESP]
dc.contributor.authorPavan, Leticia [UNESP]
dc.contributor.authorCarvalho, Cibele Figueira [UNESP]
dc.contributor.authorCanola, Júlio Carlos [UNESP]
dc.contributor.authorVicente, Wilter Ricardo Russiano [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:12:21Z
dc.date.available2018-12-11T17:12:21Z
dc.date.issued2017-05-01
dc.description.abstractThe aim of this study was to evaluate and compare the efficacy of B-mode, Doppler, contrast- enhanced ultrasonography (CEUS), and Acoustic Radiation Force Impulse (ARFI) elastography in predicting malignancy in canine mammary masses. This was a prospective cohort study from 2014 to 2016, which included 153 bitches with one or more mammary masses. A total of 300 masses were evaluated by ultrasonography (B-mode, Doppler, CEUS, and ARFI) and subsequently classified as benign or malignant by histopathology. Each ultrasound parameters studied were compared between benign and malignant masses by Chi-square or Student tests and differences were considered significant when P < 0.01. For the variables that proved significant differences were estimated the cut-off point, sensitivity, specificity, accuracy, and area under curve (AUC) by receiver-operating characteristic curve (ROC) analysis in a logistic regression model using histopathological classification as reference, to assess and compare diagnostic performance of each technique. Out of 300 mammary masses evaluated 246 were classified as malignant and 54 as benign. Bmode measurements showed sensitivity 67.9%, and specificity 67.6% as malignancy predictors on canine mammary masses; Doppler indexes systolic (>21.2 m/s) and diastolic velocity (>4.8 m/s) sensitivity 79.2% and specificity 70.8%; CEUS wash-out time (<80.5 s) sensitivity 80.2% and specificity 16.7%; and ARFI elastography shear velocity (SWV > 2.57 m/s) sensitivity 94.7% and specificity 97.2% In conclusion B-mode and Doppler ultrasound evaluations may assist in malignancy prediction of canine mammary masses with moderate sensitivity and specificity, already the SWV was an great accurate predictor. Therefore, ARFI elastography exam inclusion in veterinary clinic oncology and research is highly recommended, since it allows fast, non-invasive, and complication-free malignancy prediction of canine mammary masses.en
dc.description.affiliationDepartment of Animal Reproduction Campus Jaboticabal School of Agrarian Sciences and Veterinary Medicine UNESP-Universidade Estadual Paulista Julio de Mesquita Filho
dc.description.affiliationDepartment of Veterinary Clinics and Surgery Campus Jaboticabal School of Agrarian Sciences and Veterinary Medicine UNESP-Universidade Estadual Paulista Julio de Mesquita Filho
dc.description.affiliationUnespDepartment of Animal Reproduction Campus Jaboticabal School of Agrarian Sciences and Veterinary Medicine UNESP-Universidade Estadual Paulista Julio de Mesquita Filho
dc.description.affiliationUnespDepartment of Veterinary Clinics and Surgery Campus Jaboticabal School of Agrarian Sciences and Veterinary Medicine UNESP-Universidade Estadual Paulista Julio de Mesquita Filho
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0178143
dc.identifier.citationPLoS ONE, v. 12, n. 5, 2017.
dc.identifier.doi10.1371/journal.pone.0178143
dc.identifier.file2-s2.0-85019945571.pdf
dc.identifier.issn1932-6203
dc.identifier.scopus2-s2.0-85019945571
dc.identifier.urihttp://hdl.handle.net/11449/174671
dc.language.isoeng
dc.relation.ispartofPLoS ONE
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleUltrasonography methods for predicting malignancy in canine mammary tumorsen
dc.typeArtigo

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Artigos - Medicina Veterinária Preventiva e Reprodução Animal - FCAV
Artigos - Clínica e Cirurgia Veterinária - FCAV