Spatial and seasonal analysis of antimicrobials and toxicity tests with Daphnia magna, on the sub-basin of Piracicaba river, SP, Brazil

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dc.contributor.authorTorres, Nádia Hortense
dc.contributor.authorde Salles Pupo, Marilia Moura
dc.contributor.authorFerreira, Luiz Fernando Romanholo
dc.contributor.authorMaranho, Lucineide Aparecida
dc.contributor.authorAmérico-Pinheiro, Juliana Heloisa Pinê [UNESP]
dc.contributor.authorVilca, Franz Zirena
dc.contributor.authorde Hollanda, Luciana Maria
dc.contributor.authorTornisielo, Valdemar Luiz
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionTiradentes University (UNIT)
dc.contributor.institutionInstitute for Technology and Research
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNational University of Toribio Rodriguez de Mendoza de Amazonas
dc.date.accessioned2018-12-11T17:16:06Z
dc.date.available2018-12-11T17:16:06Z
dc.date.issued2017-12-01
dc.description.abstractAntimicrobials are pharmaceuticals considered micropollutants because they are found in wastewaters at low concentrations (ng L−1), which is the case of Enrofloxacin (ENR), Erythromycin (ERY), Norfloxacin (NOR) and Ciprofloxacin (CIP). These compounds are used to treat respiratory, urinary, sexually transmitted diseases, and skin infections being excreted by the body. Due to their composition they are considered of high risk to flora and fauna. The goal of this work was to determine possible concentration of Enrofloxacin, Erythromycin, Norfloxacin and Ciprofloxacin in water, after methodology validation to analyze and monitor the antimicrobials in superficial water and urban supply. Thus, liquid chromatography coupled with mass spectrometer with electrospray ionization source (LC-ESI–MS/MS) was used. The results obtained showed limit of detection (LOD) varying from 0.1 to 0.8 ng L−1; linearity was obtained in the gap between 10 and 200 ng L−1 for Erythromycin, and 40–200 ng L−1 for Ciprofloxacin, Norfloxacin and Enrofloxacin. Regression coefficients (r2) were over 0.9 and recovery rates were between 82 and 118% of the samples spiked with 50 and 100 ng L−1. This validated methodology was successfully used to determine antimicrobials level in water samples collected along Piracicaba River and treated water samples of Piracicaba city. From these samples, the antimicrobial mostly found was Norfloxacin in concentrations varying from 8 to 18 ng L−1 in samples collected in dry seasons, whereas Ciprofloxacin, Enrofloxacin and Erythromycin were not found in any of the samples collected. For the 48 h acute tests with Daphnia magna, Norfloxacin and Erythromycin were considered as “low toxicity”, while other compounds did not present any toxicity effect.en
dc.description.affiliationEcotoxicology Laboratory Center for Nuclear Energy in Agriculture University of Sao Paulo, Av. Centenário, 303, Postal Code: 96
dc.description.affiliationProcesses Engineering Tiradentes University (UNIT), Av. Murilo Dantas, 300
dc.description.affiliationInstitute for Technology and Research, Av. Murilo Dantas, 300 (Prédio do ITP)
dc.description.affiliationUNESP Aquiculture Center UNESP, Rua Prof. Paulo Donato Castellane, s/n
dc.description.affiliationNational University of Toribio Rodriguez de Mendoza de Amazonas Departament of Civil and Environmental Engineering, Calle Higos Urcos, 342-350-356
dc.description.affiliationUnespUNESP Aquiculture Center UNESP, Rua Prof. Paulo Donato Castellane, s/n
dc.format.extent6070-6076
dc.identifierhttp://dx.doi.org/10.1016/j.jece.2017.11.031
dc.identifier.citationJournal of Environmental Chemical Engineering, v. 5, n. 6, p. 6070-6076, 2017.
dc.identifier.doi10.1016/j.jece.2017.11.031
dc.identifier.file2-s2.0-85034579565.pdf
dc.identifier.issn2213-3437
dc.identifier.scopus2-s2.0-85034579565
dc.identifier.urihttp://hdl.handle.net/11449/175508
dc.language.isoeng
dc.relation.ispartofJournal of Environmental Chemical Engineering
dc.relation.ispartofsjr0,924
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAquatic environment
dc.subjectEnvironmental contamination
dc.subjectMass spectrometer
dc.subjectSuperficial water
dc.titleSpatial and seasonal analysis of antimicrobials and toxicity tests with Daphnia magna, on the sub-basin of Piracicaba river, SP, Brazilen
dc.typeArtigo

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