Rol protector de la melatonina en el daño de la espermatogénesis en ratón producido por arsenito de sodio

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dc.contributor.authorBustos-Obregón, Eduardo
dc.contributor.authorPoblete, Daniel
dc.contributor.authorCatriao, Roberto
dc.contributor.authorFernandes, Fábio Henrique [UNESP]
dc.contributor.institutionUniversidad de La Frontera
dc.contributor.institutionUniversity Santo Tomás
dc.contributor.institutionUniversity of Chile Medical School
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T18:58:53Z
dc.date.available2022-04-28T18:58:53Z
dc.date.issued2013-12-03
dc.description.abstractArsenic is a testicular environmental toxic. Melatonin (Me), being a potent antioxidant, may reduce the damage caused by arsenic in male fertility. The effects of daily oral exposure of Sodium Arsenite (As; 7.0 mg/kg/bw); Melatonin (Me, 10.0 mg/kg/bw); Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw), and Negative Control (NaCl 0.9%) in male CF-1 adult mice were assessed in acute (8.3 days), chronic (33.2 days) and recovery (66,4 days) of testicular damage. We evaluated changes in testicular weight and histopathological, morphometric measurements, expression of COX-2 and Androgen Receptor (AR) antigens and lipid peroxidation levels. Treatment resulted in decreased tubular diameter and AR expression, and increased: interstitial area, luminal diameter, COX-2 expression levels and of lipid peroxidation. Co-administration of As and Me partially decreased germ cell degeneration and AR expression levels, improving testicular histopathological parameters. These results indicate that As causes toxicity and testicular germ cell degeneration by induction of oxidative stress. Me partially protects from this damage in mouse testis, acting as scavenger of oxygen radical species.en
dc.description.affiliationVID Universidad de La Frontera, Temuco
dc.description.affiliationVeterinary School University Santo Tomás, Santiago
dc.description.affiliationUniversity of Chile Medical School, Santiago
dc.description.affiliationSão Paulo State University, Botucatu
dc.description.affiliationUnespSão Paulo State University, Botucatu
dc.format.extent849-856
dc.identifierhttp://dx.doi.org/10.4067/S0717-95022013000300012
dc.identifier.citationInternational Journal of Morphology, v. 31, n. 3, p. 849-856, 2013.
dc.identifier.doi10.4067/S0717-95022013000300012
dc.identifier.issn0717-9367
dc.identifier.issn0717-9502
dc.identifier.scopus2-s2.0-84888423680
dc.identifier.urihttp://hdl.handle.net/11449/219981
dc.language.isoeng
dc.language.isospa
dc.relation.isnodouble229626*
dc.relation.ispartofInternational Journal of Morphology
dc.sourceScopus
dc.subjectAndrogen receptor
dc.subjectArsenic
dc.subjectCOX-2
dc.subjectMelatonin
dc.subjectMouse
dc.subjectOxidative stress
dc.titleRol protector de la melatonina en el daño de la espermatogénesis en ratón producido por arsenito de sodioes
dc.title.alternativeProtective role of melatonin in mouse spermatogenesis induced by sodium arseniteen
dc.typeArtigo

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