Accuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosis

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dc.contributor.authorMoriguchi, Sônia Marta [UNESP]
dc.contributor.authorDe Luca, Laurival Antonio [UNESP]
dc.contributor.authorGriva, Beatriz Lotufo [UNESP]
dc.contributor.authorKoga, Katia Hiromoto [UNESP]
dc.contributor.authorDa Silva, Eduardo Tinois
dc.contributor.authorVespoli, Heloísa Maria de Luca [UNESP]
dc.contributor.authorUemura, Gilberto [UNESP]
dc.contributor.institutionBarretos Canc Hosp
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:15Z
dc.date.available2014-05-20T13:33:15Z
dc.date.issued2010-01-01
dc.description.abstractScintimammography using Tc-99m-sestamibi is a noninvasive and painless diagnostic imaging method that is used to detect breast cancer when mammography is inconclusive Because of the advantages of labeling v '7,ith Tc-99m-sestamibi and its high efficiency in detecting carcinomas, it is the most widespread agent for this purpose Its accumulation in the tumor has multifactorial causes and does not depend on the presence of architectural distortion or local or diffuse density variation in the breast The objective of tfiis study was to evaluate the accuracy of scintimammography 1 for detecting breast cancer One hundred and fifty-seven patients presenting 158 palpable and non-palpable breast nodules were evaluated Three patients were male and 154 were female, aged between 14 and 81 years All patients underwent scintimammography, and the nodule was subjected i to cytological or histological study, i e, the gold standard for diagnosing cancer One hundred and eleven malignant and 47 benign nodules were detected, with predominance of ductal carcinomas (n=94) and fibroadenoma/fibrocysiic condition (n=11/n=11), respectively The mean size was 3 11 cm (7-10 cm) among the malignant nodules and 2 07 cm among the benign nodules (0 5-10 cm) The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 89, 89, 95, 78 and 89%, respectively Analysis on the histological types showed that the technique was more effective on tumors that were more aggressive, such as ductal carcinoma In this study, Tc-99m-sestamibi scintim immography was shown to be an important tool for diagnosing breast cancer when mammography was inconclusiveen
dc.description.affiliationBarretos Canc Hosp, Dept Nucl Med, BR-14784400 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Nucl Med, Botucatu Med Sch, BR-18618970 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Obstet & Gynecol, Botucatu Med Sch, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Nucl Med, Botucatu Med Sch, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Obstet & Gynecol, Botucatu Med Sch, BR-18618970 São Paulo, Brazil
dc.format.extent205-209
dc.identifierhttp://dx.doi.org/10.3892/etm_00000033
dc.identifier.citationExperimental and Therapeutic Medicine. Athens: Spandidos Publ Ltd, v. 1, n. 1, p. 205-209, 2010.
dc.identifier.doi10.3892/etm_00000033
dc.identifier.issn1792-0981
dc.identifier.lattes9878648143577124
dc.identifier.lattes8550647632202059
dc.identifier.urihttp://hdl.handle.net/11449/11368
dc.identifier.wosWOS:000284562100033
dc.language.isoeng
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofExperimental and Therapeutic Medicine
dc.relation.ispartofjcr1.410
dc.relation.ispartofsjr0,510
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectscintimammographyen
dc.subjectbreast canceren
dc.subjectTc-99m-sestamibien
dc.titleAccuracy of Tc-99m-sestamibi scintimammography for breast cancer diagnosisen
dc.typeArtigo
dcterms.licensehttp://www.spandidos-publications.com/pages/terms
dcterms.rightsHolderSpandidos Publ Ltd
unesp.author.lattes8550647632202059
unesp.author.lattes9878648143577124
unesp.author.orcid0000-0001-8270-2652[2]
unesp.author.orcid0000-0001-5834-2714[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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