Comparative analysis of tissue reactions to anesthetic solutions: histological analysis in subcutaneous tissue of rats.

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dc.contributor.authorRibeiro Jr., Paulo Domingos
dc.contributor.authorSanches, Marcio Giampietro
dc.contributor.authorOkamoto, Tetuo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:59Z
dc.date.available2014-05-27T11:20:59Z
dc.date.issued2003-12-01
dc.description.abstractPostanesthetic pain is a relatively common complication after local anesthesia. This complication may be caused by the anesthetic technique or by the anesthetic solution used. Tissue reactions induced by the anesthetic solutions may be one of the factors resulting in pain after anesthesia. The objective of this study was to comparatively analyze tissue reactions induced by different anesthetic solutions in the subcutaneous tissue of rats. The following solutions were utilized: 2% lidocaine without vasoconstrictor; a 0.5% bupivacaine solution with 1:200,000 adrenaline; a 4% articaine solution and 2% mepivacaine, both with 1:100,000 adrenaline; and a 0.9% sodium chloride solution as a control. Sterilized absorbent paper cones packed inside polyethylene tubes were soaked in the solutions and implanted in the subcutaneous region. The sacrifice periods were 1, 2, 5, and 10 days after surgery. The specimens were prepared and stained with hematoxylin and eosin for histological analysis. The results showed that there is a difference in tissue irritability produced by the local anesthetic solutions. The results also showed that there is no relation between the concentration of the drug and the inflammatory intensity, that the mepivacaine and articaine solutions promoted less inflammatory reaction than the bupivacaine, and that the lidocaine solution produced the least intense inflammation.en
dc.format.extent169-180
dc.identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2007452/
dc.identifier.citationAnesthesia progress, v. 50, n. 4, p. 169-180, 2003.
dc.identifier.file2-s2.0-1542319219.pdf
dc.identifier.issn0003-3006
dc.identifier.scopus2-s2.0-1542319219
dc.identifier.urihttp://hdl.handle.net/11449/67554
dc.language.isoeng
dc.relation.ispartofAnesthesia progress
dc.relation.ispartofsjr0,293
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectadrenalin
dc.subjectarticaine
dc.subjectbupivacaine
dc.subjectirritant agent
dc.subjectlidocaine
dc.subjectlocal anesthetic agent
dc.subjectmepivacaine
dc.subjectsodium chloride
dc.subjectvasoconstrictor agent
dc.subjectanimal
dc.subjectcomparative study
dc.subjectdermatitis
dc.subjectdrug effect
dc.subjectdrug implant
dc.subjectlymphocyte
dc.subjectmacrophage
dc.subjectmale
dc.subjectneutrophil
dc.subjectpathology
dc.subjectrat
dc.subjectskin
dc.subjecttime
dc.subjectWistar rat
dc.subjectAnesthetics, Local
dc.subjectAnimals
dc.subjectBupivacaine
dc.subjectCarticaine
dc.subjectDermatitis
dc.subjectDrug Implants
dc.subjectEpinephrine
dc.subjectIrritants
dc.subjectLidocaine
dc.subjectLymphocytes
dc.subjectMacrophages
dc.subjectMale
dc.subjectMepivacaine
dc.subjectNeutrophils
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSkin
dc.subjectSodium Chloride
dc.subjectTime Factors
dc.subjectVasoconstrictor Agents
dc.titleComparative analysis of tissue reactions to anesthetic solutions: histological analysis in subcutaneous tissue of rats.en
dc.typeArtigo

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