Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes

dc.contributor.authorEbaid, Geovana Xavier [UNESP]
dc.contributor.authorSeiva, Fabio R. F. [UNESP]
dc.contributor.authorRocha, Katiucha K. H. R. [UNESP]
dc.contributor.authorSouza, Gisele A. [UNESP]
dc.contributor.authorNovelli, Ethel L. B. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:33:51Z
dc.date.available2014-05-20T15:33:51Z
dc.date.issued2010-10-19
dc.description.abstractBackground: Olive oil and its minor constituents have been recommended as important dietary therapeutic interventions in preventive medicine. However, a question remains to be addressed: what are the effects of olive oil and its phenolic compounds on obesity-induced cardiac metabolic changes?Methods: Male Wistar rats were divided into two groups (n = 24/group): (C) receiving standard-chow; (Ob) receiving hypercaloric-chow. After 21 days C and Ob groups were divided into four subgroups (n = 6/group):(C) standard-chow and saline; (C-Olive) standard-chow and olive-oil (3.0 g/kg. day); (C-Oleuropein) standard-chow and oleuropein (0.023 mg/kg/day); (C-Cafeic) standard-chow and cafeic-acid (2.66 mg/kg/day); (Ob)receiving hypercaloric-chow and saline;(Ob-Olive) hypercaloric-chow and olive-oil;(Ob-Oleuropein) hypercaloric-chow and oleuropein;(Ob-Cafeic) hypercaloric-chow and cafeic-acid. Treatments were given twice a week during 21 days.Results: After 42 days, obesity was evidenced in Ob rats from enhanced body-weight, surface-area, and body-mass-index. Energy-expenditure, oxygen consumption(VO(2)) and fat-oxidation were lower in Ob-group than in C. Despite no morphometric changes, Ob-Olive, Ob-Oleuropein and Ob-Cafeic groups had higher VO(2), fat-oxidation, myocardial beta-hydroxyacyl coenzyme-A dehydrogenase and lower respiratory-quotient than Ob. Citrate-synthase was highest in Ob-Olive group. Myocardial lipid-hydroperoxide(LH) and antioxidant enzymes were unaffected by olive-oil and its compounds in obesity condition, whereas LH was lower and total-antioxidant-substances were higher in C-Olive and C-Oleuropein than in C.Conclusions: The present study demonstrated for the first time that olive-oil, oleuropein and cafeic-acid enhanced fat-oxidation and optimized cardiac energy metabolism in obesity conditions. Olive oil and its phenolic compounds improved myocardial oxidative stress in standard-fed conditions.en
dc.description.affiliationSão Paulo State Univ, Inst Biol Sci, Dept Chem & Biochem, UNESP, BR-18618000 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Sch Med, Postgrad Course Dept Clin & Cardiol, UNESP, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Inst Biol Sci, Dept Chem & Biochem, UNESP, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Med, Postgrad Course Dept Clin & Cardiol, UNESP, BR-18618000 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1186/1475-2891-9-46
dc.identifier.citationNutrition Journal. London: Biomed Central Ltd., v. 9, p. 9, 2010.
dc.identifier.doi10.1186/1475-2891-9-46
dc.identifier.fileWOS000283732300001.pdf
dc.identifier.issn1475-2891
dc.identifier.urihttp://hdl.handle.net/11449/42335
dc.identifier.wosWOS:000283732300001
dc.language.isoeng
dc.publisherBiomed Central Ltd.
dc.relation.ispartofNutrition Journal
dc.relation.ispartofjcr3.568
dc.relation.ispartofsjr1,447
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleEffects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changesen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
dcterms.rightsHolderBiomed Central Ltd.
unesp.author.orcid0000-0002-7461-8773[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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