Chronic administration of Abarema cochliacarpos attenuates colonic inflammation in rats

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dc.contributor.authorSilva, Maria Silene da
dc.contributor.authorSánchez-Fidalgo, Susana
dc.contributor.authorCárdeno, Ana
dc.contributor.authorTalero, Elena
dc.contributor.authorSilva, Marcelo Aparecido da [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorBrito, Alba R. M. Souza
dc.contributor.authorLastra, Catalina A. de la
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversity of Seville
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:21:23Z
dc.date.available2014-05-20T14:21:23Z
dc.date.issued2011-08-01
dc.description.abstractInflammatory bowel diseases are characterized by a chronic clinical course of relapse and remission associated with self-destructive inflammation of the gastrointestinal tract. Active extracts from plants have emerged as natural potential candidates for its treatment. Abarema cochliacarpos (Gomes) Barneby & Grimes, Fabaceae (Barbatimão), is a native medicinal plant in to Brazil. Previously we have demonstrated in an acute colitis model a marked protective effect of a butanolic extract, so we decided to assess its anti-inflammatory effect in a chronic ulcerative colitis model induced by trinitrobenzensulfonic acid (TNBS). Abarema cochliacarpos (150 mg/day, v.o.) was administered for fourteen consecutive days. This treatment decreased significantly macroscopic damage as compared with TNBS. Histological analysis showed that the extract improved the microscopic structure. Myeloperoxidase activity (MPO) was significantly decreased. Study of cytokines showed that TNF-α was diminished and IL-10 level was increased after Abarema cochliacarpos treatment. In order to elucidate inflammatory mechanisms, expression of cyclooxygenase (COX)-2 and nitric oxide synthase (iNOS) were studied showing a significant downregulation. In addition, there was reduction in the JNK and p-38 activation. Finally, IκB degradation was blocked by Abarema cochliacarpos treatment being consistent with an up-regulation of the NF-kappaB-binding activity. These results reinforce the anti-inflammatory effects described previously suggesting that Abarema cochliacarpos could provide a source for the search for new anti-inflammatory compounds useful in ulcerative colitis treatment.en
dc.description.affiliationUniversidade Estadual de Campinas Departamento de Anatomia, Biologia Celular e Fisiologia e Biofísica
dc.description.affiliationUniversity of Seville Facultad de Farmacia Departamento de Farmacología
dc.description.affiliationUniversidade Estadual de São Paulo Instituto de Química Departamento de Química Orgânica
dc.format.extent680-690
dc.identifierhttp://dx.doi.org/10.1590/S0102-695X2011005000122
dc.identifier.citationRevista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 4, p. 680-690, 2011.
dc.identifier.doi10.1590/S0102-695X2011005000122
dc.identifier.fileS0102-695X2011000400018.pdf
dc.identifier.issn0102-695X
dc.identifier.lattes7927877224326837
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.scieloS0102-695X2011000400018
dc.identifier.urihttp://hdl.handle.net/11449/26390
dc.language.isoeng
dc.publisherSociedade Brasileira de Farmacognosia
dc.relation.ispartofRevista Brasileira de Farmacognosia
dc.relation.ispartofjcr1.596
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectAbarema cochliacarposen
dc.subjectchronic colitisen
dc.subjectinhibitor protein kappa Ben
dc.subjectJNKen
dc.subjectp-38en
dc.subjecttrinitrobenzensulfonic aciden
dc.titleChronic administration of Abarema cochliacarpos attenuates colonic inflammation in ratsen
dc.typeArtigo
unesp.author.lattes7927877224326837
unesp.author.orcid0000-0003-3032-2556[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept

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Artigos - Ciências Biológicas - São Vicente