Antimutagenic and anticarcinogenic effects of wheat bran in vivo

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dc.contributor.authorPesarini, J. R.
dc.contributor.authorZaninetti, P. T.
dc.contributor.authorMauro, M. O. [UNESP]
dc.contributor.authorCarreira, C. M.
dc.contributor.authorDichi, J. B.
dc.contributor.authorRibeiro, L. R. [UNESP]
dc.contributor.authorMantovani, M. S.
dc.contributor.authorOliveira, R. J.
dc.contributor.institutionCentro Universitário Filadélfia
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2014-05-27T11:29:33Z
dc.date.available2014-05-27T11:29:33Z
dc.date.issued2013-05-28
dc.description.abstractPrevious studies in rodents treated with the pro-carcinogen 1,2-dimethylhydrazine suggested that the consumption of wheat bran protected against DNA damage in the colon and rectum. Based on this information, we evaluated wheat bran as a functional food in the prevention and treatment of colon cancer. We used the aberrant crypt focus assay to evaluate the anticarcinogenic potential of wheat bran (Triticum aestivum variety CD-104), the comet assay to evaluate its antigenotoxicity potential, and the micronucleus assay to evaluate its antimutagenic potential. The wheat bran gave good antimutagenic and anticarcinogenic responses; the DNA damage decreased from 90.30 to 26.37% and from 63.35 to 28.73%, respectively. However, the wheat bran did not significantly reduce genotoxicity. Further tests will be necessary, including tests in human beings, before this functional food can be recommended as an adjunct in the prevention and treatment of colon cancer. © FUNPEC-RP.en
dc.description.affiliationCentro de Estudo em Nutrição e Genética Toxicológica Centro Universitário Filadélfia, Londrina, PR
dc.description.affiliationInstituto de Biociências de Rio Claro Universidade Estadual Paulista, Rio Claro, SP
dc.description.affiliationCentro de Estudos em Células Tronco Terapia Celular e Genética Toxicológica Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS
dc.description.affiliationCentro de Ciências da Saúde Departamento de Ciências Farmacêuticas Universidade Estadual de Londrina, Londrina, PR
dc.description.affiliationCentro de Ciências Biológicas Departamento de Biologia Universidade Estadual de Londrina, Londrina, PR
dc.description.affiliationUniversidade Federal de Mato Grosso do Sul, Campo Grande, MS
dc.description.affiliationCentro de Ciências Biológicas e da Saúde Universidade Federal de Mato Grosso do Sul, Campo Grande, MS
dc.description.affiliationUnespInstituto de Biociências de Rio Claro Universidade Estadual Paulista, Rio Claro, SP
dc.format.extent1646-1659
dc.identifierhttp://dx.doi.org/10.4238/2013.May.14.5
dc.identifier.citationGenetics and Molecular Research, v. 12, n. 2, p. 1646-1659, 2013.
dc.identifier.doi10.4238/2013.May.14.5
dc.identifier.file2-s2.0-84878104013.pdf
dc.identifier.issn1676-5680
dc.identifier.scopus2-s2.0-84878104013
dc.identifier.urihttp://hdl.handle.net/11449/75453
dc.identifier.wosWOS:000320030100078
dc.language.isoeng
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectChemoprevention
dc.subjectFunctional food
dc.subjectTriticum aestivum
dc.subjectWheat bran
dc.subjectDNA
dc.subjectanimal experiment
dc.subjectantineoplastic activity
dc.subjectapoptosis
dc.subjectcancer risk
dc.subjectcell cycle
dc.subjectcell proliferation
dc.subjectcolon cancer
dc.subjectcomet assay
dc.subjectcontrolled study
dc.subjectDNA damage
dc.subjectgenotoxicity
dc.subjectin vivo study
dc.subjectmale
dc.subjectmicronucleus test
dc.subjectmouse
dc.subjectmutagenicity
dc.subjectnonhuman
dc.subjectwheat bran
dc.titleAntimutagenic and anticarcinogenic effects of wheat bran in vivoen
dc.typeArtigo
dcterms.licensehttp://geneticsmr.com/node/2

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