Understanding the Seasonal Effect of Metabolite Production in Terminalia catappa L. Leaves through a Concatenated MS- and NMR-Based Metabolomics Approach

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dc.contributor.authorZanatta, Ana C. [UNESP]
dc.contributor.authorVieira, Natália Carolina [UNESP]
dc.contributor.authorDantas-Medeiros, Renato
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorEdrada-Ebel, RuAngelie
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Strathclyde
dc.contributor.institutionFederal University of Rio Grande do Norte
dc.date.accessioned2023-07-29T16:10:32Z
dc.date.available2023-07-29T16:10:32Z
dc.date.issued2023-03-01
dc.description.abstractTerminalia catappa L. (Combretaceae) is a medicinal plant that is part of the Brazilian biodiversity; this plant is popularly used for the treatment of a wide range of diseases. To better understand the chemical composition of T. catappa in different seasons, we conducted a thorough study using LC-MS and NMR data analysis techniques. The study helped obtain a chemical profile of the plant ethanolic extracts in different seasons of the year (spring, summer, autumn, and winter). The dereplication of LC-HRMS data allowed the annotation of 90 compounds in the extracts of T. catappa (hydrolyzable tannins, ellagic acid derivatives, and glycosylated flavonoids). Triterpenes and C-glycosyl flavones were the compounds that significantly contributed to differences observed between T. catappa plant samples harvested in autumn/winter and spring, respectively. The variations observed in the compound composition of the plant leaves may be related to processes induced by environmental stress and leaf development. Data fusion applied in the metabolomic profiling study allowed us to identify metabolites with greater confidence, and provided a better understanding regarding the production of specialized metabolites in T. catappa leaves under different environmental conditions, which may be useful to establish appropriate quality criteria for the standardization of this medicinal plant.en
dc.description.affiliationDepartment of Biochemistry and Organic Chemistry São Paulo State University (UNESP), SP
dc.description.affiliationInstitute of Biosciences São Paulo State University (UNESP), SP
dc.description.affiliationStrathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde
dc.description.affiliationDepartment of Pharmaceutical Sciences Faculty of Pharmacy Federal University of Rio Grande do Norte, RN
dc.description.affiliationUnespDepartment of Biochemistry and Organic Chemistry São Paulo State University (UNESP), SP
dc.description.affiliationUnespInstitute of Biosciences São Paulo State University (UNESP), SP
dc.identifierhttp://dx.doi.org/10.3390/metabo13030349
dc.identifier.citationMetabolites, v. 13, n. 3, 2023.
dc.identifier.doi10.3390/metabo13030349
dc.identifier.issn2218-1989
dc.identifier.scopus2-s2.0-85151996715
dc.identifier.urihttp://hdl.handle.net/11449/249838
dc.language.isoeng
dc.relation.ispartofMetabolites
dc.sourceScopus
dc.subjectdata fusion
dc.subjectplant metabolomics
dc.subjectseasonality
dc.subjectspecialized metabolites
dc.titleUnderstanding the Seasonal Effect of Metabolite Production in Terminalia catappa L. Leaves through a Concatenated MS- and NMR-Based Metabolomics Approachen
dc.typeArtigo
unesp.author.orcid0000-0003-0199-4521[1]
unesp.author.orcid0000-0003-2208-7808[3]
unesp.author.orcid0000-0003-2420-1117[5]

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