Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)

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dc.contributor.authorGarcia, Armando da Costa
dc.contributor.authorJúnior, Orivaldo Teixeira de Menezes
dc.contributor.authorMariano, Lissa Apolonia
dc.contributor.authorSantiago, Letícia Corrêa
dc.contributor.authorAraújo, Ângela Regina [UNESP]
dc.contributor.authorMonfardini, Julia Dietsche [UNESP]
dc.contributor.authorSimões, Rejane de Castro
dc.contributor.authorde Oliveira, André Correa
dc.contributor.authorRoque, Rosemary Aparecida
dc.contributor.authorTadei, Wanderli Pedro
dc.contributor.authorTeles, Helder Lopes
dc.contributor.authorde Oliveira, Camila Martins
dc.contributor.institutionInstituto de Ciências Exatas e Tecnologia
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionInstituto Nacional de Pesquisas da Amazônia
dc.contributor.institutionInstituto de Ciências Exatas e Naturais
dc.date.accessioned2023-07-29T15:12:46Z
dc.date.available2023-07-29T15:12:46Z
dc.date.issued2022-01-01
dc.description.abstractBackground: Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti. Methods: Crude extract, fractions, and isolated substances were evaluated in in-vitro assays against third-stage larvae of Aedes aegypti. Results: We isolated 3-nitropropionic acid with an LC50 of 15.172 ppm and LC90 of 18.178 ppm after 24 hours of larval exposure. Conclusions: The results indicated that 3-nitropropionic acid exerted larvicidal activity.en
dc.description.affiliationUniversidade Federal do Amazonas Instituto de Ciências Exatas e Tecnologia, AM
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, SP
dc.description.affiliationInstituto Nacional de Pesquisas da Amazônia, AM
dc.description.affiliationUniversidade Federal de Rondonópolis Instituto de Ciências Exatas e Naturais, MT
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, SP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.identifierhttp://dx.doi.org/10.1590/0037-8682-0018-2022
dc.identifier.citationRevista da Sociedade Brasileira de Medicina Tropical, v. 55.
dc.identifier.doi10.1590/0037-8682-0018-2022
dc.identifier.issn0037-8682
dc.identifier.scopus2-s2.0-85140856637
dc.identifier.urihttp://hdl.handle.net/11449/249316
dc.language.isoeng
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical
dc.sourceScopus
dc.subjectBiomonitored chemical
dc.subjectDengue
dc.subjectSecondary metabolite
dc.titleEndophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)en
dc.typeArtigo

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