Manifestações sistêmicas na doença pulmonar obstrutiva crônica

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dc.contributor.authorDourado, Victor Zuniga
dc.contributor.authorTanni, Suzana Erico [UNESP]
dc.contributor.authorVale, Simone Alves [UNESP]
dc.contributor.authorFaganello, Márcia Maria [UNESP]
dc.contributor.authorSanchez, Fernanda Figueirôa [UNESP]
dc.contributor.authorGodoy, Irma [UNESP]
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionPeixe Vivo
dc.date.accessioned2014-05-27T11:21:55Z
dc.date.available2014-05-27T11:21:55Z
dc.date.issued2006-07-04
dc.description.abstractChronic obstructive pulmonary disease is progressive and is characterized by abnormal inflammation of the lungs in response to inhalation of noxious particles or toxic gases, especially cigarette smoke. Although this infirmity primarily affects the lungs, diverse extrapulmonary manifestations have been described. The likely mechanisms involved in the local and systemic inflammation seen in this disease include an increase in the number of inflammatory cells (resulting in abnormal production of inflammatory cytokines) and an imbalance between the formation of reactive oxygen species and antioxidant capacity (leading to oxidative stress). Weakened physical condition secondary to airflow limitation can also lead to the development of altered muscle function. Chronic obstructive pulmonary disease presents diverse systemic effects including nutritional depletion and musculoskeletal dysfunction (causing a reduction in exercise tolerance), as well as other effects related to the comorbidities generally observed in these patients. These manifestations have been correlated with survival and overall health status in chronic obstructive pulmonary disease patients. In view of these facts, the aim of this review was to discuss findings in the literature related to the systemic manifestations of chronic obstructive pulmonary disease, emphasizing the role played by systemic inflammation and evaluating various therapeutic strategies.en
dc.description.affiliationUniv. Fed. Vales Jequinhonha Mucuri (UFVJM, Fed. Univ. of the Jequitinhonha and Mucuri Valleys), Diamantina, Minas Gerais
dc.description.affiliationDepartment of Pulmonology Universidade Estadual Paulista (UNESP, Paulista State University) Botucatu School of Medicine, Botucatu, São Paulo
dc.description.affiliationDepartment of Clinical Medicine Universidade Estadual Paulista (UNESP, Paulista State University) Botucatu School of Medicine, Botucatu, São Paulo
dc.description.affiliationPulmonology Department Universidade Estadual Paulista (UNESP, Paulista State University) Botucatu School of Medicine, Botucatu, São Paulo
dc.description.affiliationPeixe Vivo, 119 apto 203, Diamantina, MG
dc.description.affiliationUnespDepartment of Pulmonology Universidade Estadual Paulista (UNESP, Paulista State University) Botucatu School of Medicine, Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Clinical Medicine Universidade Estadual Paulista (UNESP, Paulista State University) Botucatu School of Medicine, Botucatu, São Paulo
dc.description.affiliationUnespPulmonology Department Universidade Estadual Paulista (UNESP, Paulista State University) Botucatu School of Medicine, Botucatu, São Paulo
dc.format.extent161-171
dc.identifierhttp://dx.doi.org/10.1590/S1806-37132006000200012
dc.identifier.citationJornal Brasileiro de Pneumologia, v. 32, n. 2, p. 161-171, 2006.
dc.identifier.doi10.1590/S1806-37132006000200012
dc.identifier.file2-s2.0-33745498457.pdf
dc.identifier.issn1806-3713
dc.identifier.scieloS1806-37132006000200012
dc.identifier.scopus2-s2.0-33745498457
dc.identifier.urihttp://hdl.handle.net/11449/68989
dc.language.isopor
dc.language.isoeng
dc.relation.ispartofJornal Brasileiro de Pneumologia
dc.relation.ispartofjcr1.532
dc.relation.ispartofsjr0,448
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectExercise tolerance
dc.subjectNeuromuscular manifestations
dc.subjectNutritional status
dc.subjectPulmonary disease, chronic obstructive/complications
dc.subjectcytokine
dc.subjectchronic obstructive lung disease
dc.subjectexercise tolerance
dc.subjecthuman
dc.subjectimmunology
dc.subjectinflammation
dc.subjectmuscle strength
dc.subjectmuscle weakness
dc.subjectnutritional disorder
dc.subjectoxidative stress
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectreview
dc.subjectskeletal muscle
dc.subjectCytokines
dc.subjectExercise Tolerance
dc.subjectHumans
dc.subjectInflammation
dc.subjectMuscle Strength
dc.subjectMuscle Weakness
dc.subjectMuscle, Skeletal
dc.subjectNutrition Disorders
dc.subjectOxidative Stress
dc.subjectPulmonary Disease, Chronic Obstructive
dc.titleManifestações sistêmicas na doença pulmonar obstrutiva crônicapt
dc.title.alternativeSystemic manifestations in chronic obstructive pulmonary diseaseen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jbpneu/paboutj.htm

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