Asymptomatic HIV-Infected Patients Present Blood Parameters Changed, According to Use of Therapy and the CD4+ T Cells Count

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dc.contributor.authorTasca, Karen Ingrid [UNESP]
dc.contributor.authorde Souza, Lenice Do Rosário [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:33:01Z
dc.date.available2023-07-29T13:33:01Z
dc.date.issued2022-01-01
dc.description.abstractIn HIV-patients, the imbalance in immunological, hematological and biochemical factors can contribute to the progression to AIDS and non-AIDS comorbidities, even during combined antiretroviral therapy (cART). In this cross-sectional study, we aimed to analyze some of these parameters in 138 different asymptomatic HIV-infected patients, doing multiple comparisons between the groups, which are dichotomized in the presence/absence of cART and type of immune response (immunological responders [iR,>500cells/mL] or non-responders [iNR,<500cells/ mL]). Were analyzed cytokines and other routine laboratory parameters. Our results showed high creatine phosphokinase and low IL-10 levels in cART-patients. They also presented metabolic alterations, including elevations in total cholesterol and triglycerides, particularly in those iNR. In ART-iR an increased alanine aminotransferase was observed. Those NAÏVE-iNR presented high LDL-cholesterol, C-reactive protein and lactate dehydrogenase values. The long-term non-progressors (LTNP) showed the best laboratory results. In conclusion, many blood parameters were changed in HIV-patients, especially in those under cART. To identify LTNP individuals could be important to discussions their early therapeutic onset.en
dc.description.affiliationDepartment of Tropical Diseases Botucatu Medical School Universidade Estadual Paulista/UNESP, São Paulo
dc.description.affiliationUnespDepartment of Tropical Diseases Botucatu Medical School Universidade Estadual Paulista/UNESP, São Paulo
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidade Estadual Paulista
dc.identifierhttp://dx.doi.org/10.1590/s2175-97902022e20808
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences, v. 58.
dc.identifier.doi10.1590/s2175-97902022e20808
dc.identifier.issn2175-9790
dc.identifier.issn1984-8250
dc.identifier.scopus2-s2.0-85144170637
dc.identifier.urihttp://hdl.handle.net/11449/248046
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.sourceScopus
dc.subjectAntiretroviral therapy
dc.subjectBiochemical exams
dc.subjectHematological exams
dc.subjectHIV/AIDS
dc.subjectMetabolic alterations
dc.subjectMetabolic dysfunctions
dc.titleAsymptomatic HIV-Infected Patients Present Blood Parameters Changed, According to Use of Therapy and the CD4+ T Cells Counten
dc.typeArtigo
unesp.author.orcid0000-0002-3664-3978[1]
unesp.author.orcid0000-0003-1948-5071[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentDoenças Tropicais e Diagnósticos por Imagem - FMBpt

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Botucatu - FMB - Faculdade de Medicina