Prenatal and pubertal exposure to 17α-ethinylestradiol cause morphological changes in the prostate of old gerbils

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dc.contributor.authorFleury, Fernanda G.
dc.contributor.authorGuimarães, Luísa R. F.
dc.contributor.authorRezende, Elisa B.
dc.contributor.authorMartins, Tracy M. M.
dc.contributor.authorCaires, Cássia R. S.
dc.contributor.authordos Santos, Fernanda C. A.
dc.contributor.authorTaboga, Sebastião R. [UNESP]
dc.contributor.authorPerez, Ana P. da S.
dc.contributor.institutionUFJ
dc.contributor.institutionFaculty of Medicine of São José do Rio Preto-FAMERP
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2022-04-29T08:30:41Z
dc.date.available2022-04-29T08:30:41Z
dc.date.issued2021-10-01
dc.description.abstractThis study evaluated such as exposure to ethinylestradiol during the prenatal (18th–22nd day) and pubertal (42nd–49th day) periods acts on the male ventral prostate and female prostate of 12-month old gerbils. We performed the analysis to serum hormone levels for estradiol and testosterone. The prostates were submitted to morphometric and immunohistochemical analyses. Exposure to ethinylestradiol during these developmental periods decreased the testosterone serum levels in males and increased the estradiol serum levels in females. Morphologically, prostate intraepithelial neoplasia and disorders in the arrangement of the fibrous components were observed in the prostate glands of both sexes of gerbil exposed to ethinylestradiol during development periods. In the male prostate, the ethinylestradiol promoted decreased in the frequency of positive epithelial cell for androgen receptor (AR) and increased the frequency of positive stromal cell for estrogen receptor α. However, in the female prostate, this synthetic estrogen caused AR upregulation and increased cell proliferation. This study shows that the exposure to ethinylestradiol during development phases alters the morphology and the hormonal signaling in the male and female prostates of old gerbils, confirming the action of ethinylestradiol as endocrine disruptor.en
dc.description.affiliationInstitute of Health Sciences Medicine Course Federal University of Jataí UFJ
dc.description.affiliationGraduate Program in Health Sciences Faculty of Medicine of São José do Rio Preto-FAMERP
dc.description.affiliationDepartment of Histology Embryology and Cell Biology Federal University of Goiás Samambaia II
dc.description.affiliationLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University-UNESP
dc.description.affiliationDepartment of Structural and Functional Biology State University of Campinas-UNICAMP
dc.description.affiliationMedicine Course and Graduate Program of Animal Bioscience Institute of Health Sciences Federal University of Jataí UFJ
dc.description.affiliationUnespLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University-UNESP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2009/16790-5
dc.description.sponsorshipIdFAPESP: 2011/06335-9
dc.format.extent2074-2085
dc.identifierhttp://dx.doi.org/10.1002/cbin.11656
dc.identifier.citationCell Biology International, v. 45, n. 10, p. 2074-2085, 2021.
dc.identifier.doi10.1002/cbin.11656
dc.identifier.issn1095-8355
dc.identifier.issn1065-6995
dc.identifier.scopus2-s2.0-85110175844
dc.identifier.urihttp://hdl.handle.net/11449/229139
dc.language.isoeng
dc.relation.ispartofCell Biology International
dc.sourceScopus
dc.subjectdevelopment
dc.subjectfemale
dc.subjectmale
dc.subjectoral contraceptive
dc.subjectprostate
dc.titlePrenatal and pubertal exposure to 17α-ethinylestradiol cause morphological changes in the prostate of old gerbilsen
dc.typeArtigo
unesp.author.orcid0000-0003-0250-2234[4]
unesp.author.orcid0000-0002-4476-6046[6]
unesp.author.orcid0000-0002-0970-4288[7]
unesp.author.orcid0000-0002-2195-2452[8]

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Botucatu - CME - Centro de Microscopia Eletrônica