Enzyme Stimuli-Responsive Nanoparticles for Bioinsecticides: An Emerging Approach for Uses in Crop Protection

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dc.contributor.authorCamara, Marcela Candido [UNESP]
dc.contributor.authorMonteiro, Renata Aparecida [UNESP]
dc.contributor.authorCarvalho, Lucas Bragança [UNESP]
dc.contributor.authorOliveira, Jhones Luiz [UNESP]
dc.contributor.authorFraceto, Leonardo F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T11:10:04Z
dc.date.available2021-06-25T11:10:04Z
dc.date.issued2021-01-11
dc.description.abstractThe encapsulation of pesticides in systems responsive to enzymes allow for greater selectivity and specificity in pest control, in addition to contributing to reducing the impact on nontarget organisms and the environment. Therefore, the objective of this study was to investigate the synthesis of zein nanoparticles loaded with a mixture of botanical insecticides with release triggered by proteolytic enzymes found in the midguts of insects and larvae. The synthesis of the nanoparticles was carried out using the antisolvent precipitation method. Nanoformulations were characterized according to size, zeta potential, encapsulation efficiency, matrix and active ingredients interaction, and morphology. The enzymatic degradation was then studied. Nanoformulations have excellent encapsulation efficiency, greater than 95%, and stability over 60 days. The enzymatic tests showed significant reduction of the initial concentration of nanoparticles in 60 min and improved the release of geraniol, which increased from 15% to 56% in the presence of trypsin. Thus, the proteolytic enzymes were able to break down zein nanoparticles and stimulate the release of active ingredients providing a significant perspective for the control of crop insects.en
dc.description.affiliationSão Paulo State University - Unesp Institute of Science and Technology, Av. Três de Março, 511
dc.description.affiliationUnespSão Paulo State University - Unesp Institute of Science and Technology, Av. Três de Março, 511
dc.format.extent106-112
dc.identifierhttp://dx.doi.org/10.1021/acssuschemeng.0c08054
dc.identifier.citationACS Sustainable Chemistry and Engineering, v. 9, n. 1, p. 106-112, 2021.
dc.identifier.doi10.1021/acssuschemeng.0c08054
dc.identifier.issn2168-0485
dc.identifier.scopus2-s2.0-85099145728
dc.identifier.urihttp://hdl.handle.net/11449/208306
dc.language.isoeng
dc.relation.ispartofACS Sustainable Chemistry and Engineering
dc.sourceScopus
dc.subjectGeraniol
dc.subjectNanopesticides
dc.subjectNeem oil
dc.subjectSmart delivery
dc.subjectTrypsin
dc.subjectZein nanoparticles
dc.titleEnzyme Stimuli-Responsive Nanoparticles for Bioinsecticides: An Emerging Approach for Uses in Crop Protectionen
dc.typeArtigo
unesp.author.orcid0000-0002-2827-2038[5]

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