Transcriptomic landscape of male and female reproductive cancers: Similar pathways and molecular signatures predicting response to endocrine therapy

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dc.contributor.authorCamargo, Ana CL. [UNESP]
dc.contributor.authorRemoli, Beatriz [UNESP]
dc.contributor.authorPortela, Luiz MF. [UNESP]
dc.contributor.authorFioretto, Mateus N. [UNESP]
dc.contributor.authorChuffa, Luiz GA. [UNESP]
dc.contributor.authorMoreno, Carlos S.
dc.contributor.authorJustulin, Luis A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionEmory University School of Medicine
dc.date.accessioned2022-04-28T19:41:28Z
dc.date.available2022-04-28T19:41:28Z
dc.date.issued2021-09-15
dc.description.abstractReproductive cancers in both genders represent serious health problems, whose incidence has significantly risen over the past decades. Although considerable differences among reproductive cancers exist, we aimed to identify similar signaling pathways and key molecular oncomarkers shared among six human reproductive cancers that can advance the current knowledge of cancer biology to propose new strategies for more effective therapies. Using a computational analysis approach, here we uncover aberrant miRNAs-mRNAs networks shared in six reproductive tumor types, and identify common molecular mechanisms strictly associated with cancer promotion and aggressiveness. Based on the fact that estrogenic and androgenic signaling pathways were most active in prostate and breast cancers, we further demonstrated that both androgen and estrogen deprivation therapy are capable of regulating the expression of the same key molecular sensors associated with endoplasmic reticulum dysfunction and cell cycle in these cancers. Overall, our data reveal a potential mechanistic framework of cellular processes that are shared among reproductive cancers, and particularly, highlight the importance of hormonal deprivation in breast and prostate cancers and potentially new biomarkers of response to these therapeutic approaches.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP)
dc.description.affiliationDepartment of Pathology and Laboratory Medicine Emory University School of Medicine, Georgia
dc.description.affiliationDepartment of Biomedical Informatics Emory University School of Medicine, Georgia
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP)
dc.description.sponsorshipASCRS Research Foundation
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: # 310
dc.description.sponsorshipIdFAPESP: 2016/2017/01063
dc.description.sponsorshipIdFAPESP: 2017/08715–0
dc.description.sponsorshipIdCNPq: 663/2018–0
dc.description.sponsorshipIdFAPESP: 7/2018/09408–6
dc.identifierhttp://dx.doi.org/10.1016/j.mce.2021.111393
dc.identifier.citationMolecular and Cellular Endocrinology, v. 535.
dc.identifier.doi10.1016/j.mce.2021.111393
dc.identifier.issn1872-8057
dc.identifier.issn0303-7207
dc.identifier.scopus2-s2.0-85109697568
dc.identifier.urihttp://hdl.handle.net/11449/221936
dc.language.isoeng
dc.relation.ispartofMolecular and Cellular Endocrinology
dc.sourceScopus
dc.titleTranscriptomic landscape of male and female reproductive cancers: Similar pathways and molecular signatures predicting response to endocrine therapyen
dc.typeArtigo
unesp.author.orcid0000-0002-0199-3396[5]

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