Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus

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dc.contributor.authorFigueiredo, Amanda [UNESP]
dc.contributor.authorAnholeto, Luís Adriano
dc.contributor.authorCola, Diego Faria [UNESP]
dc.contributor.authorFantatto, Rafaela Regina [UNESP]
dc.contributor.authorGainza, Yousmel Alemán [UNESP]
dc.contributor.authordos Santos, Isabella Barbosa [UNESP]
dc.contributor.authorViçozzi, Gabriel Pedroso
dc.contributor.authorÁvila, Daiana Silva
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.authorChagas, Ana Carolina de Souza
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionFederal University of Pampa
dc.date.accessioned2023-07-29T16:10:48Z
dc.date.available2023-07-29T16:10:48Z
dc.date.issued2023-06-01
dc.description.abstractNanoformulations containing zein nanoparticles (ZN) can promote the stability and protection of molecules with acaricidal activity. The present study sought to develop nanoformulations with ZN associated with cypermethrin (CYPE) + chlorpyrifos (CHLO) + a plant compound (citral, menthol or limonene), characterize them, and verify their efficacy against Rhipicephalus microplus ticks. Additionally, we aimed to assess its safety in nontarget nematodes found in soil at a site subjected to contamination by acaricides. The nanoformulations were characterized by dynamic light scattering and nanoparticle tracking analysis. Nanoformulations 1 (ZN+CYPE+CHLO+citral), 2 (ZN+CYPE+CHLO+menthol), and 3 (ZN+CYPE+CHLO+limonene) were measured for diameter, polydispersion, zeta potential, concentration, and encapsulation efficiency. Nanoformulations 1, 2, and 3 were evaluated in a range from 0.004 to 0.466 mg/mL on R. microplus larvae and caused mortality > 80% at concentrations above 0.029 mg/mL. The commercial acaricide Colosso® (CYPE 15 g + CHLO 25 g + citronellal 1 g) was evaluated also from 0.004 to 0.512 mg/mL and resulted in 71.9% larval mortality at 0.064 mg/mL. Formulations 1, 2, and 3 at 0.466 mg/mL showed acaricidal efficacy of 50.2%, 40.5%, and 60.1% on engorged females, respectively, while Colosso® at 0.512 mg/mL obtained only 39.4%. The nanoformulations exhibited long residual period of activity and lower toxicity to nontarget nematodes. ZN was able to protect the active compounds against degradation during the storage period. Thus, ZN can be an alternative for the development of new acaricidal formulations using lower concentrations of active compounds.en
dc.description.affiliationSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP), Rod. Prof. Paulo Donato Castellane, SP
dc.description.affiliationBrazilian Agricultural Research Corporation (EMBRAPA) Southeast Livestock Unit, Rod. Washington Luiz, Km 234 s/n, Fazenda Canchim, SP
dc.description.affiliationInstitute of Science and Technology of Sorocaba São Paulo State University (UNESP), Av. Três de março, 511, Alto da Boa Vista, SP
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Rod. Araraquara-Jaú, km 1, Campos Ville, SP
dc.description.affiliationLaboratory of Biochemistry and Toxicology in Caenorhabditis elegans Federal University of Pampa, BR 472, Km 592, RS
dc.description.affiliationUnespSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP), Rod. Prof. Paulo Donato Castellane, SP
dc.description.affiliationUnespInstitute of Science and Technology of Sorocaba São Paulo State University (UNESP), Av. Três de março, 511, Alto da Boa Vista, SP
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Rod. Araraquara-Jaú, km 1, Campos Ville, SP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipEmpresa Brasileira de Pesquisa Agropecuária
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipIdCNPq: 169777/2017-0
dc.description.sponsorshipIdEmpresa Brasileira de Pesquisa Agropecuária: 20.18.03.17.00-02
dc.description.sponsorshipIdFAPESP: 2016/06784-1, 2017/21004-5, 2017/13249-8
dc.description.sponsorshipIdFAPESP: 2018/16070-1
dc.description.sponsorshipIdFAPESP: 2019/20185-1
dc.description.sponsorshipIdUniversidade Estadual Paulista: 88882.434504/2019-01
dc.identifierhttp://dx.doi.org/10.1016/j.vetpar.2023.109918
dc.identifier.citationVeterinary Parasitology, v. 318.
dc.identifier.doi10.1016/j.vetpar.2023.109918
dc.identifier.issn1873-2550
dc.identifier.issn0304-4017
dc.identifier.scopus2-s2.0-85152097988
dc.identifier.urihttp://hdl.handle.net/11449/249845
dc.language.isoeng
dc.relation.ispartofVeterinary Parasitology
dc.sourceScopus
dc.subjectAcaricide residues
dc.subjectNanocarrier
dc.subjectNanoformulations
dc.subjectResistance
dc.subjectTick control
dc.titleAcaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplusen
dc.typeArtigo
unesp.author.orcid0000-0001-8712-2630[2]
unesp.author.orcid0000-0002-2031-7801[4]
unesp.author.orcid0000-0003-3939-0088[10]

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Artigos - Engenharia Ambiental - Sorocaba