Stage at presentation of breast cancer in Luanda, Angola - a retrospective study

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dc.contributor.authorLopes, Lygia Vieira
dc.contributor.authorMiguel, Fernando
dc.contributor.authorFreitas, Helga
dc.contributor.authorTavares, Antonio
dc.contributor.authorPangui, Salvador
dc.contributor.authorCastro, Clara
dc.contributor.authorLacerda, Goncalo Forjaz
dc.contributor.authorLongatto-Filho, Adhemar [UNESP]
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSantos, Lucio Lara
dc.contributor.institutionSagrada Esperanca Clin
dc.contributor.institutionAngolan Inst Canc Control
dc.contributor.institutionMinist Hlth
dc.contributor.institutionAzores Oncol Ctr
dc.contributor.institutionUniv Minho
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCPOM
dc.contributor.institutionCanc Registry Norway
dc.contributor.institutionArctic Univ Norway
dc.contributor.institutionKarolinska Inst
dc.contributor.institutionSamfundet Folkhalsan
dc.contributor.institutionONCOCIR Educ & Care Oncol
dc.contributor.institutionPortuguese Oncol Inst Porto
dc.date.accessioned2018-11-26T15:28:07Z
dc.date.available2018-11-26T15:28:07Z
dc.date.issued2015-10-15
dc.description.abstractBackground: It is expected that, by 2020, 15 million new cases of cancer will occur every year in the world, one million of them in Africa. Knowledge of cancer trends in African countries is far from adequate, and improvements in cancer prevention efforts are urgently needed. The aim of this study was to characterize breast cancer clinically and pathologically at presentation in Luanda, Angola; we additionally provide quality information that will be useful for breast cancer care planning in the country. Methods: Data on breast cancer cases were retrieved from the Angolan Institute of Cancer Control, from 2006 to 2014. For women diagnosed in 2009 (5-years of follow-up), demographic, clinical and pathological information, at presentation, was collected, namely age at diagnosis, parity, methods used for pathological diagnoses, tumor pathological characteristics, stage of disease and treatment. Descriptive statistics were performed. Results: The median age of women diagnosed with breast cancer in 2009 was 47 years old (range 25-89). The most frequent clinical presentation was breast swelling with axillary lymph nodes metastasis (44.9 %), followed by a mass larger than 5 cm (14.2 %) and lump (12.9 %). Invasive ductal carcinoma was the main histologic type (81.8 %). Only 10.1 % of cancer cases had a well differentiated histological grade. Cancers were diagnosed mostly at advanced stages (66.7 % in stage III and 11.1 % in stage IV). Discussion: In this study, breast cancer was diagnosed at a very advanced stage. Although it reports data from a single cancer center in Luanda, Angola it reinforces the need for early diagnosis and increasing awareness. According to the main challenges related to breast cancer diagnosis and treatment herein presented, we propose a realistic framework that would allow for the implementation of a breast cancer care program, built under a strong network based on cooperation, teaching, audit, good practices and the organization of health services. Conclusion: Angola needs urgently a program for early diagnosis of breast cancer.en
dc.description.affiliationSagrada Esperanca Clin, Luanda, Angola
dc.description.affiliationAngolan Inst Canc Control, Luanda, Angola
dc.description.affiliationMinist Hlth, Natl Publ Hlth Dept, Luanda, Angola
dc.description.affiliationAzores Oncol Ctr, Azores Canc Registry, Angra Do Heroismo, Portugal
dc.description.affiliationUniv Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal
dc.description.affiliationSao Paulo State Univ, Fac Med, Lab Med Invest LIM 14, Sao Paulo, Brazil
dc.description.affiliationCPOM, Mol Oncol Res Ctr, Barretos, Brazil
dc.description.affiliationCanc Registry Norway, Oslo, Norway
dc.description.affiliationArctic Univ Norway, Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway
dc.description.affiliationKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
dc.description.affiliationSamfundet Folkhalsan, Folkhalsan Res Ctr, Dept Genet Epidemiol, Helsinki, Finland
dc.description.affiliationONCOCIR Educ & Care Oncol, Luanda, Angola
dc.description.affiliationPortuguese Oncol Inst Porto, Expt Pathol & Therapeut Res Ctr, Oporto, Portugal
dc.description.affiliationPortuguese Oncol Inst Porto, Dept Epidemiol, Oporto, Portugal
dc.description.affiliationUnespSao Paulo State Univ, Fac Med, Lab Med Invest LIM 14, Sao Paulo, Brazil
dc.description.sponsorshipSEMED - Portugal
dc.format.extent7
dc.identifierhttp://dx.doi.org/10.1186/s12913-015-1092-9
dc.identifier.citationBmc Health Services Research. London: Biomed Central Ltd, v. 15, 7 p., 2015.
dc.identifier.doi10.1186/s12913-015-1092-9
dc.identifier.fileWOS000362868100003.pdf
dc.identifier.issn1472-6963
dc.identifier.urihttp://hdl.handle.net/11449/158561
dc.identifier.wosWOS:000362868100003
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofBmc Health Services Research
dc.relation.ispartofsjr1,151
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBreast cancer
dc.subjectAngola
dc.subjectClinical and pathological characterization
dc.titleStage at presentation of breast cancer in Luanda, Angola - a retrospective studyen
dc.typeArtigo
dcterms.rightsHolderBiomed Central Ltd
unesp.author.orcid0000-0001-9653-4581[6]
unesp.author.orcid0000-0003-2237-0128[9]
unesp.author.orcid0000-0002-0521-5655[10]

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