Comparative Pathobiology of Canine and Human Prostate Cancer: State of the Art and Future Directions

Página do item simplificado
dc.contributor.authorNascente, Eduardo de Paula
dc.contributor.authorAmorim, Renée Laufer [UNESP]
dc.contributor.authorFonseca-Alves, Carlos Eduardo [UNESP]
dc.contributor.authorde Moura, Veridiana Maria Brianezi Dignani
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-03-01T20:49:31Z
dc.date.available2023-03-01T20:49:31Z
dc.date.issued2022-06-01
dc.description.abstractFirst described in 1817, prostate cancer is considered a complex neoplastic entity, and one of the main causes of death in men in the western world. In dogs, prostatic carcinoma (PC) exhibits undifferentiated morphology with different phenotypes, is hormonally independent of aggressive character, and has high rates of metastasis to different organs. Although in humans, the risk factors for tumor development are known, in dogs, this scenario is still unclear, especially regarding castration. Therefore, with the advent of molecular biology, studies were and are carried out with the aim of identifying the main molecular mechanisms and signaling pathways involved in the carcinogenesis and progression of canine PC, aiming to identify potential biomarkers for diagnosis, prognosis, and targeted treatment. However, there are extensive gaps to be filled, especially when considering the dog as experimental model for the study of this neoplasm in humans. Thus, due to the complexity of the subject, the objective of this review is to present the main pathobiological aspects of canine PC from a comparative point of view to the same neoplasm in the human species, addressing the historical context and current understanding in the scientific field.en
dc.description.affiliationSchool of Veterinary Medicine and Animal Science Federal University of Goiás
dc.description.affiliationVeterinary Clinic Department School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)
dc.description.affiliationDepartment of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)
dc.description.affiliationUnespVeterinary Clinic Department School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3390/cancers14112727
dc.identifier.citationCancers, v. 14, n. 11, 2022.
dc.identifier.doi10.3390/cancers14112727
dc.identifier.issn2072-6694
dc.identifier.scopus2-s2.0-85131822764
dc.identifier.urihttp://hdl.handle.net/11449/241154
dc.language.isoeng
dc.relation.ispartofCancers
dc.sourceScopus
dc.subjectImmunobiology
dc.subjectmolecular biology
dc.subjectoncogenes
dc.subjectprostate carcinoma
dc.subjecttumor suppression
dc.titleComparative Pathobiology of Canine and Human Prostate Cancer: State of the Art and Future Directionsen
dc.typeResenha

Arquivos

Coleções

Artigos - Clínica Veterinária - FMVZ
Artigos - Cirurgia e Anestesiologia Veterinária - FMVZ