Chitosan/(ureasil-PEO hybrid) blend for drug delivery

Página do item simplificado
dc.contributor.authorParedes, Mayte [UNESP]
dc.contributor.authorPulcinelli, Sandra Helena [UNESP]
dc.contributor.authorPeniche, Carlos
dc.contributor.authorGoncalves, Vanessa [UNESP]
dc.contributor.authorSantilli, Celso Valentim [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCtr Technol Applicat & Nucl Dev CEADEN
dc.contributor.institutionUniv Havana
dc.date.accessioned2015-03-18T15:53:03Z
dc.date.available2015-03-18T15:53:03Z
dc.date.issued2014-11-01
dc.description.abstractThe effect of chitosan addition on the structure and drug release properties of ureasil-polyethylene oxide (U-PEO) hybrid materials was examined. The hybrids and the blends were prepared by the sol-gel route and their structural features were characterized by infrared spectroscopy, differential scanning calorimetry, X-ray powder diffraction, and small angle X-ray scattering. The different characterization techniques revealed the formation of transparent, rubbery, flexible, water-insoluble, and low crystalline chitosan/(U-PEO hybrid) blends, which could easily dissolve pramoxine (used as a model drug). The results showed that the combined addition of chitosan and pramoxine improved the compatibility of the organic and inorganic components of the U-PEO matrix, and provided a means of tailoring the amount of drug released at steady state equilibrium.en
dc.description.affiliationSao Paulo State Univ UNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationCtr Technol Applicat & Nucl Dev CEADEN, Havana, Cuba
dc.description.affiliationUniv Havana, Ctr Biomat BIOMAT, Havana, Cuba
dc.description.affiliationUnespSao Paulo State Univ UNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent233-238
dc.identifierhttp://dx.doi.org/10.1007/s10971-014-3314-8
dc.identifier.citationJournal Of Sol-gel Science And Technology. Dordrecht: Springer, v. 72, n. 2, p. 233-238, 2014.
dc.identifier.doi10.1007/s10971-014-3314-8
dc.identifier.issn0928-0707
dc.identifier.lattes9971202585286967
dc.identifier.lattes5584298681870865
dc.identifier.orcid0000-0002-8356-8093
dc.identifier.urihttp://hdl.handle.net/11449/116323
dc.identifier.wosWOS:000343131000005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal Of Sol-gel Science And Technology
dc.relation.ispartofjcr1.745
dc.relation.ispartofsjr0,477
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSol-gelen
dc.subjectHybrid materialsen
dc.subjectChitosanen
dc.subjectChitosan blendsen
dc.subjectDrug deliveryen
dc.titleChitosan/(ureasil-PEO hybrid) blend for drug deliveryen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes9971202585286967
unesp.author.lattes5584298681870865[5]
unesp.author.orcid0000-0002-8356-8093[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.departmentFísico-Química - IQARpt

Arquivos

Coleções

Araraquara - IQAR - Instituto de Química