Genome-wide association study and heritability estimate for ectopic ureters in Entlebucher mountain dogs

Página do item simplificado
dc.contributor.authorGallana, M.
dc.contributor.authorUtsunomiya, Y. T. [UNESP]
dc.contributor.authorDolf, G.
dc.contributor.authorPintor Torrecilha, R. B. [UNESP]
dc.contributor.authorFalbo, A. K.
dc.contributor.authorJagannathan, V.
dc.contributor.authorLeeb, T.
dc.contributor.authorReichler, I.
dc.contributor.authorSölkner, J.
dc.contributor.authorSchelling, C.
dc.contributor.institutionUniversity of Zurich
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Bern
dc.contributor.institutionUniversity of Natural Resources and Life Sciences
dc.date.accessioned2019-10-06T15:19:29Z
dc.date.available2019-10-06T15:19:29Z
dc.date.issued2018-12-01
dc.description.abstractAn ectopic ureter is a congenital anomaly which may lead to urinary incontinence and without a surgical intervention even to end-stage kidney disease. A genetic component contributes to the development of this anomaly in Entlebucher mountain dogs (EMD); however, its nature remains unclear. Using the Illumina CanineHD bead chip, a case–control genome-wide association study was performed to identify SNPs associated with the trait. Six loci on canine chromosomes 3, 17, 27 and 30 were identified with 16 significantly associated SNPs. There was no single outstanding SNP associated with the phenotype, and the association signals were not close to known genes involved in human congenital anomalies of the kidney or lower urinary tract. Additional research will be necessary to elucidate the potential role of the associated genes in the development of ectopic ureters in the EMD breed.en
dc.description.affiliationClinic for Reproductive Medicine Vetsuisse-Faculty University of Zurich, Winterthurerstrasse 260
dc.description.affiliationDepartment of Preventive Veterinary Medicine and Animal Reproduction School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)
dc.description.affiliationVetsuisse-Faculty Institute of Genetics University of Bern, Bremgartenstrasse 109a
dc.description.affiliationDivision of Livestock Sciences Department of Sustainable Agricultural Systems University of Natural Resources and Life Sciences, Gregor Mendel Straße 33
dc.description.affiliationVetsuisse-Faculty Clinic for Reproductive Medicine and Center of Clinical Studies University of Zurich, Eschikon 27, EHB F 22.1
dc.description.affiliationUnespDepartment of Preventive Veterinary Medicine and Animal Reproduction School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)
dc.format.extent645-650
dc.identifierhttp://dx.doi.org/10.1111/age.12728
dc.identifier.citationAnimal Genetics, v. 49, n. 6, p. 645-650, 2018.
dc.identifier.doi10.1111/age.12728
dc.identifier.issn1365-2052
dc.identifier.issn0268-9146
dc.identifier.scopus2-s2.0-85054181646
dc.identifier.urihttp://hdl.handle.net/11449/186908
dc.language.isoeng
dc.relation.ispartofAnimal Genetics
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCanis lupus familiaris
dc.subjectcongenital anomalies of the kidney and urinary tract
dc.subjectcongenital anomalies of the lower urinary tract
dc.subjectcongenital urological malformation
dc.subjectgenome-wide association study
dc.subjecturinary tract development
dc.titleGenome-wide association study and heritability estimate for ectopic ureters in Entlebucher mountain dogsen
dc.typeArtigo
unesp.author.orcid0000-0003-0553-4880[7]

Arquivos

Coleções

Artigos