Advances in the crosstalk between maternal separation and voluntary ethanol consumption and effects on reproduction

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dc.contributor.authorTeixeira, Giovana Rampazzo [UNESP]
dc.contributor.authorMartins, Otávio Augusto [UNESP]
dc.contributor.authorKremer, Rafael
dc.contributor.authorVeras, Allice Santos Cruz [UNESP]
dc.contributor.authorPinheiro, Patricia Fernanda Felipe [UNESP]
dc.contributor.authorMello-Junior, Wilson [UNESP]
dc.contributor.authorMartinez, Francisco Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.date.accessioned2023-07-29T13:28:53Z
dc.date.available2023-07-29T13:28:53Z
dc.date.issued2022-12-15
dc.description.abstractMaternal separation (SM) is an event caused by early stress and may be associated with behavioral changes and vulnerabilities, enhancing ethanol consumption in adulthood. The aim of the study was to evaluate whether MS potentiates the effects of ethanol ingestion on physiological hormone regulation and its interference in testicular and epididymal morphofunctional aspects in voluntary ethanol-consuming rats. Therefore, for the first time, we investigated the effect of maternal separation and ethanol consumption in adulthood and for this we used free choice ethanol-consuming strains. Responses of metabolic and hormonal parameters were also addressed, as well as their effects on reproductive function. In summary, MS promoted an increase in voluntary ethanol consumption in UChA and UChB animals. There was an influence of MS on the increase of circulating corticosterone and testosterone in UChB animals (high-ethanol-preferring 10 % v/v). MS performed in the hyporesponsive period to stress promoted an increase in glucose and circulating lipids, as well as a reduction in lactate dehydrogenase levels. Daily sperm production and transit time through the epididymis in UChB animals were increased by MS. Together, these findings show that MS potentiates the effects of ethanol ingestion and promotes an imbalance in plasma hormone concentrations, interfering with the reproductive functional imbalance of ethanol-consuming rats.en
dc.description.affiliationDepartment of Physical Education School of Technology and Sciences UNESP Campus of Presidente Prudente, SP
dc.description.affiliationDepartment of Cellular Biology Embryology Genetics - Federal University of Santa Catarina, Santa Catarina
dc.description.affiliationDepartment of Medicine - Federal University of Fronteira Sul, Rio Grande do Sul
dc.description.affiliationMulticenter Graduate Program in Physiological Sciences SBFIS São Paulo State University (UNESP), Campus of Araçatuba, SP
dc.description.affiliationDepartment of Animal Production and Preventive Veterinary Medicine Faculty of Veterinary Medicine and Animal Science São Paulo State University (UNESP) -, SP
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP
dc.description.affiliationUnespDepartment of Physical Education School of Technology and Sciences UNESP Campus of Presidente Prudente, SP
dc.description.affiliationUnespMulticenter Graduate Program in Physiological Sciences SBFIS São Paulo State University (UNESP), Campus of Araçatuba, SP
dc.description.affiliationUnespDepartment of Animal Production and Preventive Veterinary Medicine Faculty of Veterinary Medicine and Animal Science São Paulo State University (UNESP) -, SP
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2005/04712-1
dc.description.sponsorshipIdFAPESP: 2020/16166-9
dc.description.sponsorshipIdFAPESP: 2020/16310-2
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2022.121173
dc.identifier.citationLife Sciences, v. 311.
dc.identifier.doi10.1016/j.lfs.2022.121173
dc.identifier.issn1879-0631
dc.identifier.issn0024-3205
dc.identifier.scopus2-s2.0-85141995938
dc.identifier.urihttp://hdl.handle.net/11449/247894
dc.language.isoeng
dc.relation.ispartofLife Sciences
dc.sourceScopus
dc.subjectAlcohol-induced disorders
dc.subjectCorticosterone
dc.subjectEarly-life stress
dc.subjectPituitary-adrenal system
dc.titleAdvances in the crosstalk between maternal separation and voluntary ethanol consumption and effects on reproductionen
dc.typeArtigo
unesp.departmentEducação Física - FCTpt

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Presidente Prudente - FCT - Faculdade de Ciências e Tecnologia
Artigos - Ciências Básicas - FOA
Artigos - Produção Animal - FMVZ