The comparative efficacy of yohimbine and atipamezole to treat amitraz intoxication in dogs

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dc.contributor.authorAndrade, Silvia Franco
dc.contributor.authorSakate, Michiko [UNESP]
dc.contributor.institutionUniversidade do Oeste Paulista (UNOESTE)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:40Z
dc.date.available2014-05-27T11:20:40Z
dc.date.issued2003-06-01
dc.description.abstractThis study compared the efficacy of yohimbine with atipamezole, a new α2-adrenergic antagonist, to treat canine amitraz intoxication. Thirty dogs were divided equally into 3 groups (A, AY, and AA). Group A received 2.5% amitraz iv at 1 mg/kg; Group AY received the same dose of amitraz followed 30 min later by 0.1 mg/kg (2 mg/mL) yohimbine iv; and Group AA received the same dose of amitraz followed 30 min later by 0.2 mg/kg (5 mg/mL) atipamezole iv. Temperature, heart rate, respiratory frequency, mean arterial pressure, degree of sedation, mean time of tranquilization and diameter of pupils were monitored for 360 min. Sedation, logs of reflexes, hypothermia bradycardia, hypotension, bradypnea and mydriasis were observed in Group A, with 3rd eyelid prolapse, increased diuresis and vomiting in some animals. Yohimbine reversed all alterations induced by amitraz, but induced significant cardiorespiratory effects such as tachycardia and tachypnea. Atipamezole was a useful antagonist for amitraz, with less cardiorespiratory effects, suggesting its potential role as an alternative treatment of amitraz intoxication in dogs.en
dc.description.affiliationFac. de Med. Veterinaria da UNOESTE Campus II, Rodovia Raposo Tavares, Km 572, Presidente Prudente, SP
dc.description.affiliationFMVZ - UNESP, Botucatu, SP
dc.description.affiliationUnespFMVZ - UNESP, Botucatu, SP
dc.format.extent124-127
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12776786
dc.identifier.citationVeterinary and Human Toxicology, v. 45, n. 3, p. 124-127, 2003.
dc.identifier.issn0145-6296
dc.identifier.scopus2-s2.0-0038586378
dc.identifier.urihttp://hdl.handle.net/11449/67316
dc.identifier.wosWOS:000183036700002
dc.language.isoeng
dc.relation.ispartofVeterinary and Human Toxicology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectamitraz
dc.subjectatipamezole
dc.subjectyohimbine
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectcontrolled study
dc.subjectdog
dc.subjectdrug efficacy
dc.subjectdrug intoxication
dc.subjectectoparasite
dc.subjectingestion
dc.subjectintestine motility
dc.subjectmean arterial pressure
dc.subjectnonhuman
dc.subjectrespiration depression
dc.subjectthermoregulation
dc.subjectAdrenergic alpha-Antagonists
dc.subjectAnimals
dc.subjectDog Diseases
dc.subjectDogs
dc.subjectFemale
dc.subjectImidazoles
dc.subjectInfusions, Intravenous
dc.subjectMale
dc.subjectPoisoning
dc.subjectToluidines
dc.subjectTreatment Outcome
dc.subjectYohimbine
dc.subjectAnimalia
dc.subjectCanis familiaris
dc.titleThe comparative efficacy of yohimbine and atipamezole to treat amitraz intoxication in dogsen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Clínica Veterinária - FMVZ