Effects of isoflavone-supplemented soy yogurt on lipid parameters and atherosclerosis development in hypercholesterolemic rabbits: a randomized double-blind study

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dc.contributor.authorCavallini, Daniela Cardoso Umbelino [UNESP]
dc.contributor.authorAbdalla, Dulcineia S. P.
dc.contributor.authorVendramini, Regina Célia [UNESP]
dc.contributor.authorBedani, Raquel [UNESP]
dc.contributor.authorBomdespacho, Laura Q. [UNESP]
dc.contributor.authorPauly-Silveira, Nadiege D. [UNESP]
dc.contributor.authorde Valdez, Graciela F.
dc.contributor.authorRossi, Elizeu Antonio [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCentro de Referencia para Lactobacilos (CERELA)
dc.date.accessioned2014-05-20T13:23:43Z
dc.date.available2014-05-20T13:23:43Z
dc.date.issued2009-10-08
dc.description.abstractBackground: There is increasing interest in natural treatments to control dyslipidemia and reduce the risk of cardiovascular disease. Previous studies have demonstrated the beneficial effects of soy yogurt fermented with Enterococcus faecium CRL 183 and of dietary isoflavones on the lipid profile. The purpose of the present study was to investigate the effects of isoflavone-supplemented soy yogurt, fermented with E. faecium CRL183, on lipid parameters and atherosclerosis development in rabbits with induced hypercholesterolemia.Methods: Forty-eight rabbits were randomly assigned to eight groups fed on the following diets for 60 days: C - control; IY - isoflavone-supplemented soy yogurt; H - hypercholesterolemic (1.0% cholesterol wt/wt diet); HY - hypercholesterolemic plus soy yogurt; HIY - hypercholesterolemic plus isoflavone-supplemented soy yogurt; HP - hypercholesterolemic plus placebo; HI hypercholesterolemic plus isoflavone and HE - hypercholesterolemic plus pure culture of E. faecium CRL 183. Serum lipids and autoantibodies against oxLDL (oxLDL Ab) were analyzed on days 0, 30 and 60 of the treatment and the atherosclerotic lesions were quantified at the end of the experiment.Results: Soy yogurt, soy yogurt supplemented with isoflavones and placebo promoted significant reductions in total cholesterol level (38.1%, 27.0% and 26.6%, respectively). Significant increases in serum HDL-C concentration relative to group H were detected in animals that ingested soy yogurt, with or without the isoflavone supplement (55.2%), E. faecium culture (43.3%) or placebo (35.8%). Intake of soy yogurt and soy yogurt supplemented with isoflavones prevented the rise of oxLDL Ab during the study period. The extent of atherosclerosis in the thoracic and abdominal aortas was reduced in the HIY, HY and HP groups. However, when the whole aorta was analyzed, animals treated with soy yogurt supplemented with isoflavones exhibited the greatest reduction (51.4%, P < 0.05) in atherosclerotic lesion area, compared to group H.Conclusion: Soy yogurt could be consumed as an alternative means of reducing the risk of cardiovascular disease by improving the lipid profile and inhibiting oxLDL Ab formation. Our findings also suggest that isoflavone supplementation may enhance the antiatherosclerotic effect of soy yogurt.en
dc.description.affiliationSão Paulo State Univ, Dept Food & Nutr, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Clin Anal, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationCERELA, Reference Ctr Lactobacilos, San Miguel de Tucuman, Argentina
dc.description.affiliationUnespSão Paulo State Univ, Dept Food & Nutr, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Clin Anal, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent10
dc.identifierhttp://dx.doi.org/10.1186/1476-511X-8-40
dc.identifier.citationLipids In Health and Disease. London: Biomed Central Ltd., v. 8, p. 10, 2009.
dc.identifier.doi10.1186/1476-511X-8-40
dc.identifier.fileWOS000271234000001.pdf
dc.identifier.issn1476-511X
dc.identifier.lattes7641979287850489
dc.identifier.lattes3242858535763793
dc.identifier.urihttp://hdl.handle.net/11449/7206
dc.identifier.wosWOS:000271234000001
dc.language.isoeng
dc.publisherBiomed Central Ltd.
dc.relation.ispartofLipids in Health and Disease
dc.relation.ispartofjcr2.663
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleEffects of isoflavone-supplemented soy yogurt on lipid parameters and atherosclerosis development in hypercholesterolemic rabbits: a randomized double-blind studyen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
dcterms.rightsHolderBiomed Central Ltd.
unesp.author.lattes7641979287850489
unesp.author.lattes3242858535763793
unesp.author.orcid0000-0002-8016-0447[5]
unesp.author.orcid0000-0001-6806-085X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAlimentos e Nutrição - FCFpt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas