Administração de toxina botulínica A e a orquiectomia no tratamento da hiperplasia prostática benigna do cão

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Mostachio, Giuliano Queiroz
Apparício, Maricy [UNESP]
Motheo, Tathiana Ferguson [UNESP]
Alves, Aracélle Elisane
Vicente, Wilter Ricardo Russiano [UNESP]

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The pathogenesis of benign prostatic hyperplasia (BPH) is not completely known, however, dihydrotestosterone is a hormone involved in enlargement of the prostate. Recently, the effect of botulinum toxin A (BT-A) was investigated and has shown to induce atrophy of the gland. Based on that, the aims of this study were to compare the effects of administration of BT-A with orchiectomy in the treatment of BPH, in addition to assessing the effects of BT-A on libido and semen quality. Therefore, 16 sexually intact male dogs were submitted to orchiectomy or administration of 500U BT-A, and evaluated for 16 weeks. Orchiectomy presented excellent results, reducing the prostate volume up to 80%. Administration of BT-A did not interfered on libido, erection or semen characteristics. On the other hand, reduced significantly the prostate volume. The results suggest that intraprostatic injection of BT-A is an effective alternative treatment without adverse effects for valuable breeding dogs with BPH. However, this therapy showed lower reduction of prostate volume when compared to orchiectomy.



BPH, Dog, Neurotoxin, Orchiectomy, Prostate, Semen

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Ciencia Rural, v. 45, n. 9, p. 1654-1659, 2015.