Administração de toxina botulínica A e a orquiectomia no tratamento da hiperplasia prostática benigna do cão

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dc.contributor.authorMostachio, Giuliano Queiroz
dc.contributor.authorApparício, Maricy [UNESP]
dc.contributor.authorMotheo, Tathiana Ferguson [UNESP]
dc.contributor.authorAlves, Aracélle Elisane
dc.contributor.authorVicente, Wilter Ricardo Russiano [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.date.accessioned2018-12-11T17:25:37Z
dc.date.available2018-12-11T17:25:37Z
dc.date.issued2015-01-01
dc.description.abstractThe pathogenesis of benign prostatic hyperplasia (BPH) is not completely known, however, dihydrotestosterone is a hormone involved in enlargement of the prostate. Recently, the effect of botulinum toxin A (BT-A) was investigated and has shown to induce atrophy of the gland. Based on that, the aims of this study were to compare the effects of administration of BT-A with orchiectomy in the treatment of BPH, in addition to assessing the effects of BT-A on libido and semen quality. Therefore, 16 sexually intact male dogs were submitted to orchiectomy or administration of 500U BT-A, and evaluated for 16 weeks. Orchiectomy presented excellent results, reducing the prostate volume up to 80%. Administration of BT-A did not interfered on libido, erection or semen characteristics. On the other hand, reduced significantly the prostate volume. The results suggest that intraprostatic injection of BT-A is an effective alternative treatment without adverse effects for valuable breeding dogs with BPH. However, this therapy showed lower reduction of prostate volume when compared to orchiectomy.en
dc.description.affiliationDepartamento de Clínica Cirúrgica de Pequenos Animais, Centro Universitário de Rio Preto (UNIRP), BR 153, Km 69
dc.description.affiliationDepartamento de Reprodução Animal, Universidade Estadual Paulista (UNESP)
dc.description.affiliationDepartamento de Cirurgia, Universidade Federal de Uberlândia (UFU)
dc.description.affiliationUnespDepartamento de Reprodução Animal, Universidade Estadual Paulista (UNESP)
dc.format.extent1654-1659
dc.identifierhttp://dx.doi.org/10.1590/0103-8478cr20141253
dc.identifier.citationCiencia Rural, v. 45, n. 9, p. 1654-1659, 2015.
dc.identifier.doi10.1590/0103-8478cr20141253
dc.identifier.fileS0103-84782015000901654.pdf
dc.identifier.issn1678-4596
dc.identifier.issn0103-8478
dc.identifier.scieloS0103-84782015000901654
dc.identifier.scopus2-s2.0-84940105599
dc.identifier.urihttp://hdl.handle.net/11449/177468
dc.language.isopor
dc.relation.ispartofCiencia Rural
dc.relation.ispartofsjr0,337
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBPH
dc.subjectDog
dc.subjectNeurotoxin
dc.subjectOrchiectomy
dc.subjectProstate
dc.subjectSemen
dc.titleAdministração de toxina botulínica A e a orquiectomia no tratamento da hiperplasia prostática benigna do cãopt
dc.title.alternativeBotulinum toxin A administration and orchiectomy in the treatment of canine benign prostatic hyperplasiaen
dc.typeArtigo

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Artigos - Medicina Veterinária Preventiva e Reprodução Animal - FCAV