Nanosynthesis of silver-calcium glycerophosphate: Promising association against oral pathogens

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dc.contributor.authorFernandes, Gabriela Lopes [UNESP]
dc.contributor.authorDelbem, Alberto Carlos Botazzo [UNESP]
dc.contributor.authorDo Amaral, Jackeline Gallo [UNESP]
dc.contributor.authorGorup, Luiz Fernando
dc.contributor.authorFernandes, Renan Aparecido [UNESP]
dc.contributor.authorNeto, Francisco Nunes De Souza
dc.contributor.authorSouza, José Antonio Santos [UNESP]
dc.contributor.authorMonteiro, Douglas Roberto
dc.contributor.authorHunt, Alessandra Marçal Agostinho
dc.contributor.authorCamargo, Emerson Rodrigues
dc.contributor.authorBarbosa, Debora Barros [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionFederal University of Grande Dourados
dc.contributor.institutionUniversity Center of Adamantina (UNIFAI)
dc.contributor.institutionUniversity of Western São Paulo (UNOESTE)
dc.contributor.institutionMichigan State University
dc.date.accessioned2018-12-11T17:21:21Z
dc.date.available2018-12-11T17:21:21Z
dc.date.issued2018-07-01
dc.description.abstractNanobiomaterials combining remineralization and antimicrobial abilities would bring important benefits to control dental caries. This study aimed to produce nanocompounds containing calcium glycerophosphate (CaGP) and silver nanoparticles (AgNP) by varying the reducing agent of silver nitrate (sodium borohydride (B) or sodium citrate (C)), the concentration of silver (1% or 10%), and the CaGP forms (nano or commercial), and analyze its characterization and antimicrobial activity against ATCC Candida albicans (10231) and Streptococcus mutans (25175) by the microdilution method. Controls of AgNP were produced and silver ions (Ag+) were quantified in all of the samples. X-ray diffraction, UV-Vis, and scanning electron microscopy (SEM) analysis demonstrated AgNP associated with CaGP. Ag+ ions were considerably higher in AgCaGP/C. C. albicans was susceptible to nanocompounds produced with both reducing agents, regardless of Ag concentration and CaGP form, being Ag10%CaGP-N/C the most effective compound (19.5-39.0 μg Ag mL-1). While for S. mutans, the effectiveness was observed only for AgCaGP reduced by citrate, also presenting Ag10%CaGP-N the highest effectiveness (156.2-312.5 μg Ag mL-1). Notably, CaGP enhanced the silver antimicrobial potential in about two-and eight-fold against C. albicans and S. mutans when compared with the AgNP controls (from 7.8 to 3.9 and from 250 to 31.2 μg Ag mL-1, respectively). The synthesis that was used in this study promoted the formation of AgNP associated with CaGP, and although the use of sodium borohydride (B) resulted in a pronounced reduction of Ag+, the composite AgCaGP/B was less effective against the microorganisms that were tested.en
dc.description.affiliationDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Pediatric Dentistry and Public Health School of Dentistry Araçatuba São Paulo State University (UNESP)
dc.description.affiliationDepartment of Chemistry Federal University of São Carlos
dc.description.affiliationFACET—Department of Chemistry Federal University of Grande Dourados
dc.description.affiliationDepartment of Dentistry University Center of Adamantina (UNIFAI)
dc.description.affiliationUniversity of Western São Paulo (UNOESTE)
dc.description.affiliationDepartment of Microbiology and Molecular Genetics Michigan State University
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Pediatric Dentistry and Public Health School of Dentistry Araçatuba São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifierhttp://dx.doi.org/10.3390/antibiotics7030052
dc.identifier.citationAntibiotics, v. 7, n. 3, 2018.
dc.identifier.doi10.3390/antibiotics7030052
dc.identifier.file2-s2.0-85049528766.pdf
dc.identifier.issn2079-6382
dc.identifier.scopus2-s2.0-85049528766
dc.identifier.urihttp://hdl.handle.net/11449/176558
dc.language.isoeng
dc.relation.ispartofAntibiotics
dc.relation.ispartofsjr1,063
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCalcium glycerophosphate
dc.subjectCandida albicans
dc.subjectNanoparticles
dc.subjectSilver
dc.subjectStreptococcus mutans
dc.titleNanosynthesis of silver-calcium glycerophosphate: Promising association against oral pathogensen
dc.typeArtigo
unesp.author.lattes0421571920582994[2]
unesp.author.orcid0000-0002-8159-4853[2]

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Artigos - Odontologia Infantil e Social - FOA