Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism

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da Silva, Lidia Maria Rebolho Batista
da Silva, Jéssika Nunes Gomes
Galbiatti, Ana Lívia Silva
Succi, Maysa
Ruiz, Mariangela Torreglosa [UNESP]
Raposo, Luiz Sérgio
Maniglia, José Víctor
Pavarino-Bertelli, Érika Cristina
Goloni-Bertollo, Eny Maria

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Objective: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics. Methods: Retrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) by Restriction Fragment Length Polymorphism (RFLP) Analysis. Multiple logistic regression and chi-square tests were used in the statistical analysis. Results: Multivariable analysis showed that smoking and age over 42 years were disease predictors (p < 0.05). MTHFD1 1958GA or AA genotypes were associated with smoking (p = 0.04) and alcoholism (p = 0.03) and were more ofen found in more advanced stage tumors (p = 0.04) and in patients with a shorter survival (p = 0.03). Conclusion: Te presence of MTHFD1 G1948A polymorphism associated with smoking and alcoholism raises the head and neck cancer risk.



Alcoholism, Genetic, Head and neck neoplasms, Me-hylenetetrahydrofolate dehydrogenase (NADP), Polymorphism, Smoking

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Revista da Associacao Medica Brasileira, v. 57, n. 2, p. 188-193, 2011.