Effects of losartan on ventricular remodeling in experimental infarction in rats

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dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorSpadaro, Joel [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:07:14Z
dc.date.available2014-05-20T15:07:14Z
dc.date.issued2000-12-01
dc.description.abstractOBJECTIVE: To evaluate the effects of losartan on ventricular remodeling and on survival after myocardial infarction in rats. METHODS: After surgical occlusion of left coronary artery, 84 surviving male Wistar rats were divided into two groups: LO treated with losartan (20mg/kg/day, n=33) and NT (n=51), without medication. After 3 months, we analyzed mortality; ventricular to body mass ratio (VM /BM); myocardial hydroxyproline concentration (HOP); isovolumetric pressure, +dp/dt, -dp/dt, and diastolic volume/left ventricle mass ratio (VO/LV). RESULTS: Mortality was: LO = 22%, and NT = 47% (p<0.05). Ventricular mass,(VM/BM, mg/g) was 4.14 ± 0.76 and 3.54±0.48, in the NT and LO groups, respectively (p<0.05). HOP (median) was 4.92 upsilong/mg in the LO and 5.54 upsilong/g in the NT group (p>0.05). The V0/LV values (median) were 0.24 mL/g in group LO and 0.31 mL/g in group NT (p<0.05) compared to NT group. There were no differences between the groups for +dp/dt and -dp/dt parameters. CONCLUSION: 1- The use of losartan myocardial infarction causes an attenuation of ventricular remodeling, bringing about an increased survival, an attenuation of ventricular hypertrophy and dilation, and an improvement of the isovolumetric pressure; 2- the treatment does not modify the myocardial collagen concentration.en
dc.description.affiliationUNESP Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUNESP Faculdade de Medicina de Botucatu
dc.format.extent465-470
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X2000001200001
dc.identifier.citationArquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 6, p. 465-470, 2000.
dc.identifier.doi10.1590/S0066-782X2000001200001
dc.identifier.fileS0066-782X2000001200001.pdf
dc.identifier.issn0066-782X
dc.identifier.lattes6309835137998766
dc.identifier.lattes6990977122340795
dc.identifier.lattes5016839015394547
dc.identifier.scieloS0066-782X2000001200001
dc.identifier.scopus2-s2.0-0041347620
dc.identifier.urihttp://hdl.handle.net/11449/26424
dc.language.isoeng
dc.publisherSociedade Brasileira de Cardiologia (SBC)
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.relation.ispartofjcr1.318
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectfibrosisen
dc.subjectventricular functionen
dc.subjectangiotensin IIen
dc.titleEffects of losartan on ventricular remodeling in experimental infarction in ratsen
dc.typeArtigo
unesp.author.lattes5016839015394547
unesp.author.lattes6309835137998766
unesp.author.lattes6990977122340795
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

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Botucatu - FMB - Faculdade de Medicina