Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient

dc.contributor.authorLaurenti, Karen Cristina
dc.contributor.authorAlbuquerque Haach, Lourdes Cristina de
dc.contributor.authorSantos, Arnaldo Rodrigues dos
dc.contributor.authorDomingos de Almeida Rollo, Joao Manuel
dc.contributor.authorMenezes Reiff, Rodrigo Bezerra de
dc.contributor.authorMinarelli Gaspar, Ana Maria [UNESP]
dc.contributor.authorPurquerio, Benedito de Moraes
dc.contributor.authorFortulan, Carlos Alberto
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv ABC
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:49Z
dc.date.available2014-12-03T13:10:49Z
dc.date.issued2014-05-01
dc.description.abstractThis study presents an innovative and original biomaterial designed to substitute for articular cartilage and mimic its mechanical behavior, including elastic cushioning and the characteristics of fiber-reinforced gel. The material was composed of polyurethane and bioglass microfiber 45S5. It was designed to present a tribological surface to the cartilage of the tibial plateau, and to convert over a functional gradient to an osteointegrable region for self-anchorage to the subchondral bone. The biomaterial samples showed no toxicity and promoted cell spreading. Subsequent in vivo studies in rabbits demonstrated the formation of a rigid structure similar to bone trabeculae in the distal region of the tribological surface of the implant. The tribological surface of the proximal region showed a fibrocartilaginous tissue with highly vascularized chondrocytes, thus validating the proposed concept for the design of the implant incorporating a functional gradient and auto-stability.en
dc.description.affiliationUniv Sao Paulo, Dept Mech Engn, BR-13566590 Sao Carlos, SP, Brazil
dc.description.affiliationUniv ABC, Ctr Nat Sci & Humanities, BR-09210971 Santo Andre, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Bioengn Interunits, BR-13566590 Sao Carlos, SP, Brazil
dc.description.affiliationFed Univ Sao Carlos UFSCar, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio de Mesquita, UNESP, Lab Morfol, BR-14801903 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio de Mesquita, UNESP, Lab Morfol, BR-14801903 Sao Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCAPES: PE 0652008481500/2007-3
dc.format.extent638-649
dc.identifierhttp://dx.doi.org/10.1590/S1516-14392014005000030
dc.identifier.citationMaterials Research-ibero-american Journal Of Materials. Sao Carlos: Univ Fed Sao Carlos, Dept Engenharia Materials, v. 17, n. 3, p. 638-649, 2014.
dc.identifier.doi10.1590/S1516-14392014005000030
dc.identifier.fileS1516-14392014000300015.pdf
dc.identifier.issn1516-1439
dc.identifier.lattes8379925533335630
dc.identifier.scieloS1516-14392014005000030
dc.identifier.urihttp://hdl.handle.net/11449/112558
dc.identifier.wosWOS:000338017600015
dc.language.isoeng
dc.publisherUniv Fed Sao Carlos, Dept Engenharia Materials
dc.relation.ispartofMaterials Research-ibero-american Journal of Materials
dc.relation.ispartofjcr1.103
dc.relation.ispartofsjr0,398
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectosteochondral defecten
dc.subjectpolyurethaneen
dc.subjectmicrofiber 45S5 bioglassen
dc.subjectcartilage repairen
dc.subjectfunctional gradienten
dc.titleCartilage Reconstruction Using Self-anchoring Implant with Functional Gradienten
dc.typeArtigo
dcterms.rightsHolderUniv Fed Sao Carlos, Dept Engenharia Materials
unesp.author.lattes8379925533335630
unesp.author.orcid0000-0002-7168-9971[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Carregando...
Imagem de Miniatura
Nome:
S1516-14392014000300015.pdf
Tamanho:
6.15 MB
Formato:
Adobe Portable Document Format