Biochemical and structural investigations of Bothropstoxin-II, a myotoxic Asp49 phospholipase A(2) from Bothrops jararacussu venom

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dc.contributor.authorMurakami, Mario T. [UNESP]
dc.contributor.authorLourenzoni, Marco R.
dc.contributor.authorArruda, Emerson Z.
dc.contributor.authorTomaz, Marcelo A.
dc.contributor.authorVicoti, Magno M. [UNESP]
dc.contributor.authorAbrego, Jose R. B. [UNESP]
dc.contributor.authorMelo, Paulo A.
dc.contributor.authorArni, Raghuvir K. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLNLS
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionInstituto Butantan
dc.date.accessioned2014-05-20T14:02:38Z
dc.date.available2014-05-20T14:02:38Z
dc.date.issued2008-09-01
dc.description.abstractBothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding.en
dc.description.affiliationIBILCE UNESP, Dept Phys, Ctr Struct & Mol Biol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationLNLS, Brazilian Synchrotron Light Lab, Ctr Struct Mol Biol, Campinas, SP, Brazil
dc.description.affiliationUFRJ, CCS, ICB, Dept Basic & Clin Pharmacol, Rio de Janeiro, Brazil
dc.description.affiliationInstituto Butantan, Ctr Appl Toxinol, São Paulo, Brazil
dc.description.affiliationUnespIBILCE UNESP, Dept Phys, Ctr Struct & Mol Biol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipCAT/CEPID
dc.format.extent1002-1008
dc.identifierhttp://eurekaselect.com/83229/article
dc.identifier.citationProtein and Peptide Letters. Sharjah: Bentham Science Publ Ltd, v. 15, n. 9, p. 1002-1008, 2008.
dc.identifier.issn0929-8665
dc.identifier.lattes9162508978945887
dc.identifier.orcid0000-0003-2460-1145
dc.identifier.urihttp://hdl.handle.net/11449/22085
dc.identifier.wosWOS:000259509800020
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofProtein and Peptide Letters
dc.relation.ispartofjcr1.039
dc.relation.ispartofsjr0,429
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectphospholipases A(2)en
dc.subjectsuraminen
dc.subjectpharmacological activitiesen
dc.subjectstructural studiesen
dc.titleBiochemical and structural investigations of Bothropstoxin-II, a myotoxic Asp49 phospholipase A(2) from Bothrops jararacussu venomen
dc.typeArtigo
dcterms.licensehttp://www.benthamscience.com/permission.php
dcterms.rightsHolderBentham Science Publ Ltd
unesp.author.lattes9162508978945887[8]
unesp.author.orcid0000-0003-2460-1145[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentFísica - IBILCEpt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas