Sister-chromatid exchanges in β-thalassaemic patients under conditions of in vivo and in vitro depletion of folic acid

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dc.contributor.authorSilva, A. E. [UNESP]
dc.contributor.authorManzato, A. J. [UNESP]
dc.contributor.authorVarella-Garcia, M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:17:28Z
dc.date.available2014-05-27T11:17:28Z
dc.date.issued1992-07-02
dc.description.abstractIn order to investigate the effect of folate depletion, lymphocyte sister-chromatid exchange (SCE) rates were compared among homozygous β-thalassaemic patients with low folic acid levels, heterozygous β-thalassaemic patients with normal folate levels and healthy persons with normal haemoglobin, in cultures with both normal and depleted folate conditions. Significantly higher SCE rates were found in homozygous patients in all assays, but the in vitro folate depletion did not induce an increase in SCE frequency in any group.en
dc.description.affiliationDepartamento de Biologia Instituto de Biociencias Letras e Ciencias Exatas, UNESP, Caixa Postal 136, 15055 Sao Jose do Rio Preto, SP
dc.description.affiliationUnespDepartamento de Biologia Instituto de Biociencias Letras e Ciencias Exatas, UNESP, Caixa Postal 136, 15055 Sao Jose do Rio Preto, SP
dc.format.extent213-217
dc.identifierhttp://dx.doi.org/10.1016/0165-7992(92)90098-3
dc.identifier.citationMutation Research - Mutation Research Letters, v. 282, n. 3, p. 213-217, 1992.
dc.identifier.doi10.1016/0165-7992(92)90098-3
dc.identifier.issn0165-7992
dc.identifier.scopus2-s2.0-0026740527
dc.identifier.urihttp://hdl.handle.net/11449/64248
dc.language.isoeng
dc.relation.ispartofMutation Research - Mutation Research Letters
dc.relation.ispartofsjr0,662
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectβ-Thalassaemia
dc.subjectCulture conditions
dc.subjectFollic acid
dc.subjectSister-chromatid exchange
dc.subjectfolic acid
dc.subjectbeta thalassemia
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectheterozygote
dc.subjecthomozygote
dc.subjecthuman
dc.subjecthuman cell
dc.subjectlymphocyte culture
dc.subjectpriority journal
dc.subjectsister chromatid exchange
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAnalysis of Variance
dc.subjectCells, Cultured
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFolic Acid Deficiency
dc.subjectHuman
dc.subjectInfant
dc.subjectLymphocytes
dc.subjectSister Chromatid Exchange
dc.subjectSupport, Non-U.S. Gov't
dc.subjectThalassemia
dc.titleSister-chromatid exchanges in β-thalassaemic patients under conditions of in vivo and in vitro depletion of folic aciden
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes2503906319038306[1]
unesp.author.orcid0000-0003-1491-8878[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia - IBILCEpt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas