Complexity Measures of Heart-Rate Variability in Amyotrophic Lateral Sclerosis with Alternative Pulmonary Capacities

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dc.contributor.authorPimentel, Renata M. M.
dc.contributor.authorFerreira, Celso
dc.contributor.authorValenti, Vitor [UNESP]
dc.contributor.authorGarner, David M.
dc.contributor.authorMacedo Jr, Hugo
dc.contributor.authorBulle Oliveira, Acary S.
dc.contributor.authorCardoso Leitao, Francisco Naildo
dc.contributor.authorAbreu, Luiz Carlos de
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Univ FMABC
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionOxford Brookes Univ
dc.contributor.institutionFac Med ABC
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.date.accessioned2021-06-25T11:52:20Z
dc.date.available2021-06-25T11:52:20Z
dc.date.issued2021-02-01
dc.description.abstractObjective: the complexity of heart-rate variability (HRV) in amyotrophic lateral sclerosis (ALS) patients with different pulmonary capacities was evaluated. Methods: We set these according to their pulmonary capacity, and specifically forced vital capacity (FVC). We split the groups according to FVC (FVC > 50% (n = 29) and FVC < 50% (n = 28)). In ALS, the presence of an FVC below 50% is indicative of noninvasive ventilation with two pressure levels and with the absence of other respiratory symptoms. As the number of subjects per group was different, we applied the unbalanced one-way analysis of variance (uANOVA1) test after three tests of normality, and effect size by Cohen's d to assess parameter significance. Results: with regard to chaotic global analysis, CFP4 (p < 0.001; d = 0.91), CFP5 (p = 0.0022; d = 0.85), and CFP6 (p = 0.0009; d = 0.92) were enlarged. All entropies significantly increased. Shannon (p = 0.0005; d = 0.98), Renyi (p = 0.0002; d = 1.02), Tsallis (p = 0.0004; d = 0.99), approximate (p = 0.0005; d = 0.97), and sample (p < 0.0001; d = 1.22). Detrended fluctuation analysis (DFA) (p = 0.0358) and Higuchi fractal dimension (HFD) (p = 0.15) were statistically inconsequential between the two groups. Conclusions: HRV complexity in ALS subjects with different pulmonary capacities increased via chaotic global analysis, especially CFP5 and 3 out of 5 entropies.en
dc.description.affiliationFed Univ Santo Paulo UNIFESP, Dept Med, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationCtr Univ FMABC, Lab Delineamento Estudo & Escrita Cient, BR-09060650 Santo Andre, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Auton Nervous Syst Ctr CESNA, BR-17525900 Marilia, SP, Brazil
dc.description.affiliationOxford Brookes Univ, Fac Hlth & Life Sci, Dept Biol & Med Sci, Cardioresp Res Grp, Oxford OX3 0BP, England
dc.description.affiliationFac Med ABC, Dept Community Hlth, BR-09060870 Santo Andre, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Neuromuscular Dis, BR-04022002 Sao Paulo, Brazil
dc.description.affiliationFed Univ Espirito Santo UFES, Dept Integrated Hlth Educ, BR-29040090 Vitoria, ES, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Auton Nervous Syst Ctr CESNA, BR-17525900 Marilia, SP, Brazil
dc.description.sponsorshipSESACRE
dc.description.sponsorshipUFAC
dc.description.sponsorshipFMABC
dc.description.sponsorshipIdSESACRE: 007/2015
dc.description.sponsorshipIdUFAC: 007/2015
dc.description.sponsorshipIdFMABC: 007/2015
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.3390/e23020159
dc.identifier.citationEntropy. Basel: Mdpi, v. 23, n. 2, 11 p., 2021.
dc.identifier.doi10.3390/e23020159
dc.identifier.urihttp://hdl.handle.net/11449/209231
dc.identifier.wosWOS:000622501500001
dc.language.isoeng
dc.publisherMdpi
dc.relation.ispartofEntropy
dc.sourceWeb of Science
dc.subjectamyotrophic lateral sclerosis
dc.subjectautonomic nervous system
dc.subjectcardiovascular physiology
dc.subjectmotor neuron disease
dc.subjectnonlinear dynamics
dc.titleComplexity Measures of Heart-Rate Variability in Amyotrophic Lateral Sclerosis with Alternative Pulmonary Capacitiesen
dc.typeArtigo
dcterms.rightsHolderMdpi
unesp.author.orcid0000-0001-7743-2512[7]
unesp.author.orcid0000-0002-7618-2109[8]

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