Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys

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dc.contributor.authorBehling, Estela B. [UNESP]
dc.contributor.authorSendão, Milena C. [UNESP]
dc.contributor.authorFrancescato, Heloísa D.C.
dc.contributor.authorAntunes, Lusânia M.G.
dc.contributor.authorCosta, Roberto S.
dc.contributor.authorBianchi, Maria de Lourdes P.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:21:58Z
dc.date.available2014-05-27T11:21:58Z
dc.date.issued2006-09-20
dc.description.abstractQuercetin, a typical bioflavonoid ubiquitously present in fruits and vegetables, is considered to be helpful for human health. Cisplatin (cDDP) is one of the most active cytotoxic agents in the treatment of a wide range of solid tumors. The aim of this study was to investigate the possible effect of quercetin, a bioflavonoid with antioxidant potential, on cisplatin-induced nophrotoxicity and lipid peroxidation in rats. Gavage administrations of water, propylene glycol and quercetin (50 mg/kg) were made 24 and 1 h before saline or cDDP (5 mg/kg) ip injections and were repeated daily for 2, 5 or 20 subsequent days. Rats were killed 2, 5 and 20 days after ip injections, and blood and urine samples were collected to determine plasma creatinine, urine volume and osmolality. The kidneys were removed to determine the levels of thiobarbituric acid-reactive substances (TBARS) and for histological studies. Cisplatin increased lipid peroxidation, urine volume and plasma creatinine levels and decreased urine osmolality. Treatment with quercetin attenuated these alterations. These results demonstrate the role of oxidative stress and suggest a protective effect of quercetin on cisplatin-induced nephrotoxicity in adult Wistar rats. Copyright © 2006 by Institute of Pharmacology Polish Academy of Sciences.en
dc.description.affiliationDepartamento de Alimentos e Nutrição Faculdade de Ciencias Farmaceuticas de Araraquara UNESP, Rod. Araraquara/Jaú, km 01, 14801-902 Araraquara SP
dc.description.affiliationDepartamento de Análises Clínicas Toxicológicas e Bromatológicas Faculdade de Ciencias Farmaceuticas de Ribeirão Universidade de São Paulo, Av. do Café, s/n, 14040-903 Ribeirão Preto, SP
dc.description.affiliationDepartamento de Patologia Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, Av. Bandeirantes, 3900, 14040-903 Ribeirão Preto, SP
dc.description.affiliationUnespDepartamento de Alimentos e Nutrição Faculdade de Ciencias Farmaceuticas de Araraquara UNESP, Rod. Araraquara/Jaú, km 01, 14801-902 Araraquara SP
dc.format.extent526-532
dc.identifierhttp://www.if-pan.krakow.pl/pjp/cont06.html#No4
dc.identifierhttp://www.if-pan.krakow.pl/pjp/pdf/2006/4_526.pdf
dc.identifier.citationPharmacological Reports, v. 58, n. 4, p. 526-532, 2006.
dc.identifier.file2-s2.0-33748663525.pdf
dc.identifier.issn1734-1140
dc.identifier.scopus2-s2.0-33748663525
dc.identifier.urihttp://hdl.handle.net/11449/69095
dc.identifier.wosWOS:000241940100008
dc.language.isoeng
dc.relation.ispartofPharmacological Reports
dc.relation.ispartofjcr2.787
dc.relation.ispartofsjr0,773
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntioxidants
dc.subjectCisplatin
dc.subjectLipid peroxidation
dc.subjectNephrotoxicity
dc.subjectQuercetin
dc.subjectantioxidant
dc.subjectcisplatin
dc.subjectcreatinine
dc.subjectflavanoid
dc.subjectplatinil
dc.subjectpropylene glycol
dc.subjectquercetin
dc.subjectsodium chloride
dc.subjectthiobarbituric acid reactive substance
dc.subjectwater
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectcreatinine blood level
dc.subjectdrug effect
dc.subjecthistopathology
dc.subjectlipid peroxidation
dc.subjectmale
dc.subjectmultiple drug dose
dc.subjectnephrotoxicity
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectrat
dc.subjectrat strain
dc.subjecturine osmolality
dc.subjecturine volume
dc.subjectAnimals
dc.subjectAntineoplastic Agents
dc.subjectCreatinine
dc.subjectFree Radical Scavengers
dc.subjectKidney
dc.subjectKidney Diseases
dc.subjectKidney Function Tests
dc.subjectLipid Peroxidation
dc.subjectMale
dc.subjectOxidative Stress
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTime Factors
dc.titleComparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneysen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAlimentos e Nutrição - FCFpt

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