Leg Amputation for an Extensive, Severe and Intractable Sickle Cell Anemia Ulcer in a Brazilian Patient

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dc.contributor.authorMach Queiroz, Ana Maria
dc.contributor.authorCampos, Jessica
dc.contributor.authorLobo, Clarisse
dc.contributor.authorBonini-Domingos, Claudia Regina [UNESP]
dc.contributor.authorCardoso, Gilberto
dc.contributor.authorBallas, Samir K.
dc.contributor.institutionInst Hematol Arthur de Siqueira Cavalcanti HEMORI
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionThomas Jefferson Univ
dc.date.accessioned2014-12-03T13:11:06Z
dc.date.available2014-12-03T13:11:06Z
dc.date.issued2014-01-01
dc.description.abstractA 35-year-old African Brazilian patient had sickle cell anemia complicated with recurrent vasoocclusive (VOC) crises and refractory painful leg ulcers for 16 years. The ulcers started over both medial malleoli and expanded gradually. The ulcer on the left leg spread from the foot to the knee circumferentially and was refractory to all forms of therapy within the frame work of multi-disciplinary care. The patient agreed to a below the knee amputation of the left leg. He felt much better after the amputation but developed severe neuropathic phantom pain that was well controlled medically. He could differentiate the sickle cell anemia and ulcer pain from the neuropathic pain. About 6 months after the amputation he had dengue fever with fatal outcome. This is the first report of treatment of refractory sickle cell anemia leg ulcer with amputation and probably the first report of a Brazilian patient with sickle cell anemia and dengue fever.en
dc.description.affiliationInst Hematol Arthur de Siqueira Cavalcanti HEMORI, Dept Hematol, Clin Hematol Div, Rio De Janeiro, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP Julio de Mesquita Fi, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Fed Fluminense, Dept Clin Med, Niteroi, RJ, Brazil
dc.description.affiliationThomas Jefferson Univ, Dept Med, Cardeza Fdn, Jefferson Med Coll, Philadelphia, PA 19107 USA
dc.description.affiliationUnespUniv Estadual Paulista UNESP Julio de Mesquita Fi, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil
dc.description.sponsorshipOffice of the Secretary of Health for the State of Rio de Janeiro, Brazil
dc.format.extent95-98
dc.identifierhttp://dx.doi.org/10.3109/03630269.2013.875476
dc.identifier.citationHemoglobin. London: Informa Healthcare, v. 38, n. 2, p. 95-98, 2014.
dc.identifier.doi10.3109/03630269.2013.875476
dc.identifier.issn0363-0269
dc.identifier.lattes3279428066176719
dc.identifier.orcid0000-0002-4603-9467
dc.identifier.urihttp://hdl.handle.net/11449/112852
dc.identifier.wosWOS:000332800500005
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofHemoglobin
dc.relation.ispartofjcr0.462
dc.relation.ispartofsjr0,381
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAmputationen
dc.subjectdengue feveren
dc.subjectleg ulceren
dc.subjectphantom painen
dc.subjectSickle cell anemiaen
dc.titleLeg Amputation for an Extensive, Severe and Intractable Sickle Cell Anemia Ulcer in a Brazilian Patienten
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderInforma Healthcare
unesp.author.lattes3279428066176719[4]
unesp.author.orcid0000-0002-4603-9467[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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