Lithium thiazolidine-4-carboxylate: Synthesis, spectroscopic characterization and preliminary in vitro cytotoxic studies in human HeLa cells

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dc.contributor.authorCorbi, Pedro P. [UNESP]
dc.contributor.authorAndrade, Fabiana C. [UNESP]
dc.contributor.authorMassabni, Antonio Carlos [UNESP]
dc.contributor.authorHeinrich, Tassiele A.
dc.contributor.authorSouza, Pedro P. C.
dc.contributor.authorCosta-Neto, Claudio M.
dc.contributor.institutionCtr Univ Araraquara UNIARA
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:30:33Z
dc.date.available2014-05-20T15:30:33Z
dc.date.issued2008-12-01
dc.description.abstractA new water-soluble lithium Salt of thiazolidine-4-carboxylic acid was synthesized and characterized by chemical and spectroscopic techniques, Elemental and mass spectrometric (ESI-MS) analyses of the solid compound fit to the composition LiC(4)H(6)NSO(2). (1)H, (13)C nuclear magnetic resonance (NMR). [(1)H-(15)N] NMR and infrared (IR) analyses permitted to elucidate the structure of the compound. Biological activity was evaluated by cytotoxic analysis using HeLa cells. Determination of cell death was assessed using a tetrazolium Salt colorimetric assay, which reflects the cells viability. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationCtr Univ Araraquara UNIARA, Assoc Sao Bento de Ensino, Dept Ciencias Biol & Saude, BR-14801320 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUSP, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 07/56317-1
dc.description.sponsorshipIdFAPESP: 06/55367-2
dc.format.extent929-931
dc.identifierhttp://dx.doi.org/10.1016/j.saa.2008.02.013
dc.identifier.citationSpectrochimica Acta Part A-molecular and Biomolecular Spectroscopy. Oxford: Pergamon-Elsevier B.V. Ltd, v. 71, n. 3, p. 929-931, 2008.
dc.identifier.doi10.1016/j.saa.2008.02.013
dc.identifier.issn1386-1425
dc.identifier.urihttp://hdl.handle.net/11449/39905
dc.identifier.wosWOS:000261118400032
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
dc.relation.ispartofjcr2.880
dc.relation.ispartofsjr0,648
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectThiazolidine-4-carboxylic aciden
dc.subjectInfrared spectroscopyen
dc.subjectNMR spectroscopyen
dc.subjectCytotoxicityen
dc.titleLithium thiazolidine-4-carboxylate: Synthesis, spectroscopic characterization and preliminary in vitro cytotoxic studies in human HeLa cellsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.departmentQuímica Inorgânica - IQARpt

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