Exposure to crack cocaine causes adverse effects on marine mussels Perna perna

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Data

2017-10-15

Autores

Maranho, L. A.
Fontes, M. K.
Kamimura, A. S. S.
Nobre, C. R.
Moreno, B. B.
Pusceddu, F. H.
Cortez, F. S.
Lebre, D. T.
Marques, J. R.
Abessa, D. M. S. [UNESP]

Título da Revista

ISSN da Revista

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Editor

Elsevier B.V.

Resumo

Our study aimed to evaluate crack cocaine effects in different life stages of the marine mussel Perna perm. For this purpose, fertilization rate, embryo-larval development, lysosomal membrane stability and DNA strand breaks were assessed. Effect concentrations in gametes and in larval development were found after 1 h (IC50 = 23.53 mg.L-1) and 48 h (IC50 = 16.31 mg.L-1),respectively. The highest tested concentration showing no acute toxicity (NOEC) was 10 mg.L-1, while the lowest observed effect concentration (LOEC) was 20 mg.L-1. NOEC concerning embryo-larval development was 0.625 mg.L-1, while the LOEC was 1.25 mg.L-1. Cyto-genotoxic effects were evidenced in mussels exposed to crack cocaine concentrations ranging from 5 to 500 mu g.L-1. Our results report the first data on effects of an illicit drug to marine organisms and should encourage further ecotoxicological studies of these contaminants of emerging concern in coastal ecosystems.

Descrição

Palavras-chave

Crack cocaine, Bioassays, Cyto-genotoxicity, Marine organism

Como citar

Marine Pollution Bulletin. Oxford: Pergamon-elsevier Science Ltd, v. 123, n. 1-2, p. 410-414, 2017.