Immunohistochemical features of multifocal melanoacanthoma in the hard palate: A case report

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dc.contributor.authorDas Chagas E Silva de Carvalho, Luis Felipe [UNESP]
dc.contributor.authorFarina, Vitor Hugo [UNESP]
dc.contributor.authorCabral, Luiz Antonio Guimarães [UNESP]
dc.contributor.authorBrandão, Adriana Aigotti Haberbeck [UNESP]
dc.contributor.authorColetta, Ricardo Della
dc.contributor.authorAlmeida, Janete Dias [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFederal University of ABC
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-27T11:28:16Z
dc.date.available2014-05-27T11:28:16Z
dc.date.issued2013-01-30
dc.description.abstractBackground: Melanoacanthoma (MA) has been described in the oral mucosa as a solitary lesion or, occasionally, as multiple lesions. MA mainly affects dark skinned patients and grows rapidly, showing a plane or slightly raised appearance and a brown to black color. The differential diagnosis includes oral nevi, amalgam tattoos, and melanomas. We report here the case of a 58-year-old black woman who presented multiple pigmented lesions on the hard palate. Case presentation. Based on the differential diagnosis of melanoma, a punch biopsy (4 mm in diameter) was performed. The material was fixed in 10% formalin, embedded in paraffin, and stained with hematoxylin-eosin or submitted to immunohistochemical analysis. Immunohistochemistry using antibodies against protein S-100, melan-A, HMB-45, MCM-2, MCM-5, Ki-67 and geminin was performed. Immunohistochemical analysis revealed strong cytoplasmic immunoreactivity of dendritic melanocytes for proteinS-100, HMB-45 and melan-A.Positive staining for proliferative markers (MCM-2, MCM-5, Ki-67) was only observed in basal and suprabasal epithelial cells, confirming the reactive etiology of the lesion. The diagnosis was oral Melanoacanthoma (MA). Conclusion: The patient has been followed up for 30 months and shows no clinical alterations. MA should be included in the differential diagnosis of pigmented lesions of the oral cavity. © 2013 das Chagas e Silva de Carvalho et al.; licensee BioMed Central Ltd.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis São José Dos Campos Dental School São Paulo State University (UNESP), São Paulo
dc.description.affiliationNanosciences and Advanced Materials Federal University of ABC, Santo André, São Paulo
dc.description.affiliationDepartment of Oral Diagnosis Piracicaba Dental School University of Campinas, Piracicaba, São Paulo
dc.description.affiliationFaculdade de Odontologia de São José Dos Campos - UNESP Departamento de Biociências e Diagnóstico Bucal, Av. Francisco José Longo, 777 São Dimas, 12245-000, Sao Jose dos Campos, Sao Paulo
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis São José Dos Campos Dental School São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespFaculdade de Odontologia de São José Dos Campos - UNESP Departamento de Biociências e Diagnóstico Bucal, Av. Francisco José Longo, 777 São Dimas, 12245-000, Sao Jose dos Campos, Sao Paulo
dc.identifierhttp://dx.doi.org/10.1186/1756-0500-6-30
dc.identifier.citationBMC Research Notes, v. 6, n. 1, 2013.
dc.identifier.doi10.1186/1756-0500-6-30
dc.identifier.file2-s2.0-84872764879.pdf
dc.identifier.issn1756-0500
dc.identifier.lattes9514297710569236
dc.identifier.scopus2-s2.0-84872764879
dc.identifier.urihttp://hdl.handle.net/11449/74435
dc.language.isoeng
dc.relation.ispartofBMC Research Notes
dc.relation.ispartofsjr0,691
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectMelanoacanthoma
dc.subjectMouth
dc.subjectPigmented lesions
dc.subjectacanthoma
dc.subjectcase report
dc.subjectfemale
dc.subjecthard palate
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectmouth tumor
dc.subjectpathology
dc.subjectAcanthoma
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMiddle Aged
dc.subjectMouth Neoplasms
dc.subjectPalate, Hard
dc.titleImmunohistochemical features of multifocal melanoacanthoma in the hard palate: A case reporten
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
unesp.author.lattes9514297710569236
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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