Cellular immunity in Holstein cows seropositive for Bovine Leukosis Virus (BLV) during the transition period

dc.contributor.authorGomes, V.
dc.contributor.authorBaldacim, V. A. P.
dc.contributor.authorCosta, J. F. R.
dc.contributor.authorCosta e Silva, C. P.
dc.contributor.authorArcaro, J. R. P.
dc.contributor.authorMiranda, M. S.
dc.contributor.authorSousa, R. S.
dc.contributor.authorFagliari, J. J. [UNESP]
dc.contributor.authorMadureira, K. M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionApta
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.date.accessioned2018-11-29T05:57:15Z
dc.date.available2018-11-29T05:57:15Z
dc.date.issued2017-11-01
dc.description.abstractThis research evaluated the dynamics of leukocytes and lymphocytes subsets in seropositive Holstein cows for BLV during the transition period. Blood samples (n= 72) from 12 cows were harvested from week -2 up to week + 3 to perform leukogram, immunophenotyping, cortisol and haptoglobin (Hp). Leukocytes pattern was characterized by leukocytosis, neutrophilia, monocytosis and eosinopenia around calving. Lymphocytosis and high proportions of B cells CD21+ were a constant finding between week -2 and + 3, thus cows were tested and confirmed seropositive for BLV. The values of T lymphocytes subsets were low during the transition period, observing two peaks that coincided with high levels of cortisol at delivery (2.11 mu g/dL) and week + 3 (1.97 mu g/dL). Hp had gradual increase from week -2 (166 mu g/mL) until week + 3 (576g/mL) probably due to high rate of uterine infection detected between week + 2 and + 3. The seropositive cows for BLV presented stress leukogram around delivery, except for lymphocytes. Lymphocytosis and the high proportions of B cells, associated with the low proportions of T lymphocytes, can be indicative of immunosuppression and predisposition to the inflammatory process observed in the post-partum period.en
dc.description.affiliationUniv Sao Paulo, Fac Med Vet & Zootecnia, Sao Paulo, SP, Brazil
dc.description.affiliationApta, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil
dc.description.affiliationUniv Fed Bahia, Escola Med Vet & Zootecnia, Salvador, BA, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil
dc.format.extent1367-1375
dc.identifierhttp://dx.doi.org/10.1590/1678-4162-8982
dc.identifier.citationArquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 69, n. 6, p. 1367-1375, 2017.
dc.identifier.doi10.1590/1678-4162-8982
dc.identifier.fileS0102-09352017000601367.pdf
dc.identifier.issn0102-0935
dc.identifier.scieloS0102-09352017000601367
dc.identifier.urihttp://hdl.handle.net/11449/165965
dc.identifier.wosWOS:000422914400002
dc.language.isopor
dc.publisherArquivo Brasileiro Medicina Veterinaria Zootecnia
dc.relation.ispartofArquivo Brasileiro De Medicina Veterinaria E Zootecnia
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectperipartum
dc.subjecthaptoglobin
dc.subjectcortisol
dc.subjectlymphocytes subsets
dc.titleCellular immunity in Holstein cows seropositive for Bovine Leukosis Virus (BLV) during the transition perioden
dc.typeArtigo
dcterms.rightsHolderArquivo Brasileiro Medicina Veterinaria Zootecnia

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