Charge effect in the interaction of doxorubicin and derivatives with polydeoxynucleotides

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dc.contributor.authorRuggiero, João [UNESP]
dc.contributor.authorXodo, Luigi E.
dc.contributor.authorCiana, Antonio
dc.contributor.authorManzini, Giorgio
dc.contributor.authorQuadrifoglio, Franco
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionInstitute of Biology, Faculty of Medicine, University of Udine
dc.date.accessioned2022-04-28T19:53:51Z
dc.date.available2022-04-28T19:53:51Z
dc.date.issued1992-02-11
dc.description.abstractThe equilibrium interaction of doxorubicin and its N-acetyl derivative with a series of purine-pyrimidine alternating polydeoxynucleotides has been studied through spectrofluorometry to assess the relevance of the electrostatic contribution to DNA intercalation. The results have shown that: (a) the suppression of the positive charge on the aminosugar has: (I) a profound negative effect on the free energy of intercalation, as expected, and (II) a negligible influence on the base specificity, which supports the notion of an essentially electrostatic effect of N-acetylation on intercalation; (b) a reasonably good accord with the demands of a polyelectrolytic model, due to Friedman and Manning, is found. © 1992.en
dc.description.affiliationPhysics Department, Institute of Biosciences, UNESP, São José do Rio Preto
dc.description.affiliationDepartment of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Trieste
dc.description.affiliationInstitute of Biology, Faculty of Medicine, University of Udine, Udine
dc.description.affiliationUnespPhysics Department, Institute of Biosciences, UNESP, São José do Rio Preto
dc.format.extent294-302
dc.identifierhttp://dx.doi.org/10.1016/0167-4781(92)90506-U
dc.identifier.citationBBA - Gene Structure and Expression, v. 1129, n. 3, p. 294-302, 1992.
dc.identifier.doi10.1016/0167-4781(92)90506-U
dc.identifier.issn0167-4781
dc.identifier.scopus2-s2.0-0026515431
dc.identifier.urihttp://hdl.handle.net/11449/223933
dc.language.isoeng
dc.relation.ispartofBBA - Gene Structure and Expression
dc.sourceScopus
dc.subjectDoxorubicin
dc.subjectDrug-DNA intercalation
dc.subjectPolyelectrolyte effect
dc.titleCharge effect in the interaction of doxorubicin and derivatives with polydeoxynucleotidesen
dc.typeArtigo

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