Charge effect in the interaction of doxorubicin and derivatives with polydeoxynucleotides
dc.contributor.author | Ruggiero, João [UNESP] | |
dc.contributor.author | Xodo, Luigi E. | |
dc.contributor.author | Ciana, Antonio | |
dc.contributor.author | Manzini, Giorgio | |
dc.contributor.author | Quadrifoglio, Franco | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Institute of Biology, Faculty of Medicine, University of Udine | |
dc.date.accessioned | 2022-04-28T19:53:51Z | |
dc.date.available | 2022-04-28T19:53:51Z | |
dc.date.issued | 1992-02-11 | |
dc.description.abstract | The equilibrium interaction of doxorubicin and its N-acetyl derivative with a series of purine-pyrimidine alternating polydeoxynucleotides has been studied through spectrofluorometry to assess the relevance of the electrostatic contribution to DNA intercalation. The results have shown that: (a) the suppression of the positive charge on the aminosugar has: (I) a profound negative effect on the free energy of intercalation, as expected, and (II) a negligible influence on the base specificity, which supports the notion of an essentially electrostatic effect of N-acetylation on intercalation; (b) a reasonably good accord with the demands of a polyelectrolytic model, due to Friedman and Manning, is found. © 1992. | en |
dc.description.affiliation | Physics Department, Institute of Biosciences, UNESP, São José do Rio Preto | |
dc.description.affiliation | Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Trieste | |
dc.description.affiliation | Institute of Biology, Faculty of Medicine, University of Udine, Udine | |
dc.description.affiliationUnesp | Physics Department, Institute of Biosciences, UNESP, São José do Rio Preto | |
dc.format.extent | 294-302 | |
dc.identifier | http://dx.doi.org/10.1016/0167-4781(92)90506-U | |
dc.identifier.citation | BBA - Gene Structure and Expression, v. 1129, n. 3, p. 294-302, 1992. | |
dc.identifier.doi | 10.1016/0167-4781(92)90506-U | |
dc.identifier.issn | 0167-4781 | |
dc.identifier.scopus | 2-s2.0-0026515431 | |
dc.identifier.uri | http://hdl.handle.net/11449/223933 | |
dc.language.iso | eng | |
dc.relation.ispartof | BBA - Gene Structure and Expression | |
dc.source | Scopus | |
dc.subject | Doxorubicin | |
dc.subject | Drug-DNA intercalation | |
dc.subject | Polyelectrolyte effect | |
dc.title | Charge effect in the interaction of doxorubicin and derivatives with polydeoxynucleotides | en |
dc.type | Artigo |