Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus

Página do item simplificado
dc.contributor.authorBrião, Fabio Ferreira da Cunha
dc.contributor.authorHorta, Marcio Leal
dc.contributor.authorHorta, Bernardo Lessa
dc.contributor.authorde Barros, Guilherme Antônio Moreira
dc.contributor.authorBehrensdorf, Ana Paula
dc.contributor.authorSevero, Ingrid
dc.contributor.authorNunes, Mariana Antunes
dc.contributor.authorBoabaid, Roberta
dc.contributor.authorReal, André
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:46:47Z
dc.date.available2018-12-11T16:46:47Z
dc.date.issued2015-07-01
dc.description.abstractBACKGROUND AND OBJECTIVES: The prophylactic effect of ondansetron on subarachnoid morphine-induced pruritus is controversial, while evidence suggests that droperidol prevents pruritus. The aim of this study is to compare the effects of droperidol and ondansetron on subarachnoid morphine-induced pruritus. METHODS: 180 ASA I or II patients scheduled to undergo cesarean sections under subarachnoid anesthesia combined with morphine 0.2mg were randomized to receive, after the child's birth, metoclopramide 10mg (Group I - control), droperidol 2.5mg (Group II) or ondansetron 8mg (Group III). Postoperatively, the patients were assessed for pruritus (absent, mild, moderate or severe) or other side effects by blinded investigators. Patients were also blinded to their group allocation. The tendency to present more severe forms of pruritus was compared between groups. NNT was also determined. RESULTS: Patients assigned to receive droperidol [Proportional odds ratio: 0.45 (95% confidence interval 0.23-0.88)] reported less pruritus than those who received metoclopramide. Ondansetron effect was similar to metoclopramide [Proportional odds ratio: 0.95 (95% confidence interval 0.49-1.83)]. The NNT for droperidol and ondansetron was 4.0 and 14.7, respectively. CONCLUSIONS: Ondansetron does not inhibit subarachnoid morphine-induced pruritus.en
dc.description.affiliationAnesthesiology, Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brazil. Electronic address: marciolealhorta@gmail.com
dc.description.affiliationAnesthesiology, Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brazil
dc.description.affiliationEpidemiology, Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil
dc.description.affiliationUniversidade Estadual Paulista, Faculdade de Medicina de Botucatu (UNESP), Pelotas, RS, Brazil
dc.description.affiliationUniversidade Católica de Pelotas (UCPel), Pelotas, RS, Brazil
dc.format.extent244-248
dc.identifierhttp://dx.doi.org/10.1016/j.bjane.2013.11.005
dc.identifier.citationBrazilian journal of anesthesiology (Elsevier), v. 65, n. 4, p. 244-248, 2015.
dc.identifier.doi10.1016/j.bjane.2013.11.005
dc.identifier.file2-s2.0-85016924419.pdf
dc.identifier.issn0104-0014
dc.identifier.scopus2-s2.0-85016924419
dc.identifier.urihttp://hdl.handle.net/11449/169601
dc.language.isoeng
dc.relation.ispartofBrazilian journal of anesthesiology (Elsevier)
dc.relation.ispartofsjr0,288
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDroperidol
dc.subjectInjeção subaracnoidea
dc.subjectMorfina
dc.subjectMorphine
dc.subjectOndansetron
dc.subjectPrurido
dc.subjectPruritus
dc.subjectSubarachnoid injection
dc.titleComparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritusen
dc.typeArtigo

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
2-s2.0-85016924419.pdf
Tamanho:
388.99 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar

Coleções

Artigos