Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice

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dc.contributor.authorGouveia, M. C.P. [UNESP]
dc.contributor.authorMinto, B. W. [UNESP]
dc.contributor.authorSargi, L. F. [UNESP]
dc.contributor.authorSouza, R. L.
dc.contributor.authorPazzini, J. M.
dc.contributor.authorColodel, E. M.
dc.contributor.authorSilva, V. C.P.
dc.contributor.authorCassino, P. C. [UNESP]
dc.contributor.authorDias, L. G.G.G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Mato Grosso
dc.contributor.institutionUnião das Faculdades dos Grandes Lagos
dc.date.accessioned2022-04-28T19:49:24Z
dc.date.available2022-04-28T19:49:24Z
dc.date.issued2021-01-01
dc.description.abstractThe aim of this study was to evaluate the topical application of alcoholic extracts of Dipteryx alata Vogel almonds and bark in skin wound healing in mice. Fifty-four C57BL/6 mice were equally distributed into three groups: Control, Almond, and Bark. A 9 mm skin fragment was resected from the dorsal region of the animals’ thorax. The wounds were submitted to topical application of base cream (vehicle), 10% hydroalcoholic almond extract, or bark extract twice a day. Macroscopic, histological, and immunohistochemical evaluations were conducted on the 7th, 14th, and 21st postoperative days. No significant difference was observed regarding skin wound area among groups, with the parameter presenting only a temporal effect on healing (p>0.05). The almond and control groups exhibited more intense collagenization than the bark group (p<0.05). Dipteryx alata Vogel showed to be inert in the wound healing process in miceen
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinária, SP
dc.description.affiliationUniversidade Federal de Mato Grosso, MT
dc.description.affiliationUnião das Faculdades dos Grandes Lagos, SP
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinária, SP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2018/25061-6
dc.format.extent1315-1322
dc.identifierhttp://dx.doi.org/10.1590/1678-4162-12289
dc.identifier.citationArquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 73, n. 6, p. 1315-1322, 2021.
dc.identifier.doi10.1590/1678-4162-12289
dc.identifier.issn1678-4162
dc.identifier.issn0102-0935
dc.identifier.scopus2-s2.0-85122588219
dc.identifier.urihttp://hdl.handle.net/11449/223215
dc.language.isoeng
dc.relation.ispartofArquivo Brasileiro de Medicina Veterinaria e Zootecnia
dc.sourceScopus
dc.subjectBaru
dc.subjectEpithelialization
dc.subjectLeguminosae
dc.subjectPhytotherapic
dc.subjectSkin wounds
dc.titleEvaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 miceen
dc.titleAvaliação do extrato alcoólico da casca e da semente da Dipteryx alata Vogel na cicatrização da pele de camundongos C57BL/6pt
dc.typeArtigo
unesp.author.orcid0000-0001-7928-068X[1]
unesp.author.orcid0000-0002-8808-4127[2]
unesp.author.orcid0000-0001-7632-1239[3]
unesp.author.orcid0000-0002-8079-7181[4]
unesp.author.orcid0000-0002-5406-5825[5]
unesp.author.orcid0000-0002-0048-9702[6]
unesp.author.orcid0000-0002-4563-0394[7]
unesp.author.orcid0000-0003-2664-0770[8]
unesp.author.orcid0000-0003-3993-1649[9]

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