The role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of Diabetes mellitus: A review

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dc.contributor.authorMeneguin, Andreia Bagliotti [UNESP]
dc.contributor.authorSilvestre, Amanda Leticia Polli [UNESP]
dc.contributor.authorSposito, Larissa [UNESP]
dc.contributor.authorSouza, Mauricio Palmeira Chaves de [UNESP]
dc.contributor.authorSabio, Rafael Miguel [UNESP]
dc.contributor.authorAraujo, Victor Hugo Sousa [UNESP]
dc.contributor.authorCury, Beatriz Stringhetti Ferreira [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-26T01:58:47Z
dc.date.available2021-06-26T01:58:47Z
dc.date.issued2021-03-15
dc.description.abstractOral administration of insulin (INS) would represent a revolution in the treatment of diabetes, considering that this route mimics the physiological dynamics of endogenous INS. Nano- and microencapsulation exploiting the advantageous polysaccharides properties has been considered an important technological strategy to protect INS against harsh conditions of gastrointestinal tract, in the same time that improve the permeability via transcellular and/or paracellular pathways, safety and in some cases even selectivity for targeting delivery of INS. In fact, some polysaccharides also give to the systems functional properties such as pH-responsiveness, mucoadhesiveness under specific physiological conditions and increased intestinal permeability. In general, all polysaccharides can be functionalized with specific molecules becoming more selective to the cells to which INS is delivered. The present review highlights the advances in the past 10 years on micro- and nanoencapsulation of INS exploiting the unique natural properties of polysaccharides, including chitosan, starch, alginate, pectin, and dextran, among others.en
dc.description.affiliationSao Paulo State Univ, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2019/19817-3
dc.description.sponsorshipIdFAPESP: 2019/09597-6
dc.description.sponsorshipIdFAPESP: 2014/50928-2
dc.description.sponsorshipIdCNPq: 465687/2014-8
dc.format.extent20
dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2020.117504
dc.identifier.citationCarbohydrate Polymers. Oxford: Elsevier Sci Ltd, v. 256, 20 p., 2021.
dc.identifier.doi10.1016/j.carbpol.2020.117504
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/11449/210671
dc.identifier.wosWOS:000613256200001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCarbohydrate Polymers
dc.sourceWeb of Science
dc.subjectDiabetes mellitus
dc.subjectInsulin
dc.subjectPolysaccharides
dc.subjectMicroparticles
dc.subjectNanoparticles
dc.subjectOral route
dc.titleThe role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of Diabetes mellitus: A reviewen
dc.typeResenha
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0003-1957-6993[2]
unesp.author.orcid0000-0002-6118-9455[3]
unesp.author.orcid0000-0003-4983-3567[4]
unesp.author.orcid0000-0002-3852-2184[5]
unesp.author.orcid0000-0003-1731-9918[6]
unesp.author.orcid0000-0002-6698-0545[8]
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas