Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine

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dc.contributor.authorBarbisan, L. F.
dc.contributor.authorMiyamoto, M.
dc.contributor.authorScolastici, C.
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorRibeiro, L. R.
dc.contributor.authorEira, A. F.
dc.contributor.authorde Camargo, JLV
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:37:05Z
dc.date.available2014-05-20T13:37:05Z
dc.date.issued2002-11-01
dc.description.abstractThe modifying potential of prior administration of an aqueous extract of the mushroom Agaricus blazei Murrill (Agaricaceae) (Ab) on hepatotoxicity induced by different doses of diethylnitrosamine (DEN) in male Wistar rats was evaluated. During 2 weeks, animals of groups G3 (Ab+DEN50), G5 (Ab+DEN100), G7 (Ab+DEN200), and G8 (Ab-treated) were treated with the A. blazei through drinking water. After this period, groups G2 (DEN50), G3 (Ab+DEN50), G4 (DEN100) G5 (Ab+DEN100), G6 (DEN200), and G7 (Ab+DEN200) were given a single i.p. injection of 50, 100 and 200 mg/kg of DEN, respectively, while groups G1 (nontreated) and G8 (Ab-treated) were treated with 0.9% NaCl only. All animals were killed 48 h after DEN or NaCl treatments. The hepatocyte replication rate was estimated by the index of the proliferating cell nuclear antigen (PCNA) positive hepatocytes and the appearance of putative preneoplastic hepatocytes through expression of the enzyme glutathione S-transferase placental form (GSTP). After DEN-treatment, ALT levels, PCNA labeling index, and the number of GST-P positive hepatocytes were lower in rats that received A. blazei treatment and were exposed to 100 mg/kg of DEN. Our findings suggest that previous treatment with A. blazei exerts a hepatoprotective effect on both liver toxicity and hepatocarcinogenesis process induced by a moderately toxic dose of DEN. (C) 2002 Elsevier B.V. Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Patol, TOXICAN, BR-1861800 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Ciências Agron, Dept Prod Vegetal Modulo Cogumelos, BR-18603970 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Patol, TOXICAN, BR-1861800 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Ciências Agron, Dept Prod Vegetal Modulo Cogumelos, BR-18603970 Botucatu, SP, Brazil
dc.format.extent25-32
dc.identifierhttp://dx.doi.org/10.1016/S0378-8741(02)00171-X
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 83, n. 1-2, p. 25-32, 2002.
dc.identifier.doi10.1016/S0378-8741(02)00171-X
dc.identifier.issn0378-8741
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/12805
dc.identifier.wosWOS:000179153700005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAgaricus blazeipt
dc.subjectMurrillpt
dc.subjectchemoprotectionpt
dc.subjecthepatoprotectionpt
dc.subjectliver toxicitypt
dc.subjectdiethylnitrosaminept
dc.titleInfluence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamineen
dc.typeResumo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[4]
unesp.author.orcid0000-0003-3833-4172[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agronômicas, Botucatupt
unesp.departmentProdução e Melhoramento Vegetal - FCApt

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Botucatu - FCA - Faculdade de Ciências Agronômicas