Postnatal growth of the ventral prostate in Wistar rats: A stereological and morphometrical study

dc.contributor.authorVilamaior, Patricia S. L.
dc.contributor.authorTaboga, Sebastiao R.
dc.contributor.authorCarvalho, Hernandes F.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:00:26Z
dc.date.available2014-05-20T14:00:26Z
dc.date.issued2006-08-01
dc.description.abstractMorphological and stereological analyses were used to characterize the growth kinetics of the Wistar rat ventral prostate (VP). Volume density and absolute volume of the epithelium, lumen, smooth muscle cells (SMCs), and nonmuscular stroma were determined by stereology and paired with plasma testosterone levels and different morphometric measurements. The VP shows an initial growth within the first 3 weeks, a resting phase, and the puberal growth. The puberal growth was coincident with the raise in plasma testosterone. Lumen formation occurred within the 3 postnatal weeks. After an expected increase during puberty, the lumen showed a further increase at the 12th week. The volume density of the nonmuscular stroma and of the SMCs decreased slowly postnatally. Absolute volume of the luminal compartment showed three phases of growth (weeks 1-3, 6-9, and 11-12). on the other hand, the increase in the absolute volume of the epithelium was steady up to the 8th week and then showed a marked increase up the 10th week. The increase in epithelial volume was characterized morphologically by the presence of epithelial infoldings and sprouts. The growth of the epithelium showed a 2-week delay as compared to the lumen and occurred only until the 10th week. The epithelial height was variable but could be related to the synthetic activity of the epithelium. In conclusion, the postnatal growth of the VP results from a combination of epithelial proliferation/differentiation and synthesis/accumulation of the secretory products in the lumen.en
dc.description.affiliationUniv Estadual Campinas, Dept Cell Biol, Inst Biol, BR-13083863 Campinas, SP, Brazil
dc.description.affiliationUNESP, Dept Biol, IBILCE, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Dept Biol, IBILCE, São Paulo, Brazil
dc.format.extent885-892
dc.identifierhttp://dx.doi.org/10.1002/ar.a.20363
dc.identifier.citationAnatomical Record Part A-discoveries In Molecular Cellular and Evolutionary Biology. Hoboken: Wiley-liss, v. 288A, n. 8, p. 885-892, 2006.
dc.identifier.doi10.1002/ar.a.20363
dc.identifier.fileWOS000239473500006.pdf
dc.identifier.issn1552-4884
dc.identifier.lattes7066358123790434
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0001-9559-5497
dc.identifier.urihttp://hdl.handle.net/11449/21379
dc.identifier.wosWOS:000239473500006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAnatomical Record Part A-discoveries In Molecular Cellular and Evolutionary Biology
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectepithelial growthpt
dc.subjectprostate developmentpt
dc.subjectprostate secretory activitypt
dc.subjectrat ventral prostatept
dc.subjectstereologypt
dc.titlePostnatal growth of the ventral prostate in Wistar rats: A stereological and morphometrical studyen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes7066358123790434[1]
unesp.author.orcid0000-0001-9559-5497[1]
unesp.author.orcid0000-0002-0970-4288[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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