Influence of ovariectomy on healing of autogenous bone block grafts in the mandible: A histomorphometric study in an aged rat model

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dc.contributor.authorLuize, Danielle Shima [UNESP]
dc.contributor.authorBosco, Álvaro Francisco [UNESP]
dc.contributor.authorBonfante, Samara [UNESP]
dc.contributor.authorAlmeida, Juliano Milanezi de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:29:46Z
dc.date.accessioned2014-05-20T13:43:13Z
dc.date.available2013-09-30T18:29:46Z
dc.date.available2014-05-20T13:43:13Z
dc.date.issued2008-03-01
dc.description.abstractPurpose: The aim of this study was to evaluate quantitatively and qualitatively the influence of estrogen deficiency on autogenous bone block grafts in aged variectomized rats. Materials and Methods: Fifty 12-month-old female Wistar rats were used in the study. They were divided into 2 groups, an ovariectomized group and a sham-operated group. After 30 days the animals received autogenous block bone grafts on the angle of the mandible, harvested from the calvaria. The animals were euthanized at 7, 14, or 28 days postoperatively. Results: Histologic analysis showed that at 7 days postsurgery, the interface between graft and recipient site in the sham-operated group appeared filled by a granulation tissue with angiogenic activity, whereas the ovariectomized group still exhibited a blood clot and a granulation tissue in organization. on the 14th postoperative day, the interface in the shamoperated group was partially filled by newly formed bone establishing a union between the graft and the recipient site. The interface in the ovariectomized group was typically filled by granulation tissue with discrete osteogenic activity in most specimens. on the 28th postoperative day, the graft in the sham-operated group appeared histologically integrated to the mandible. However, the interface in the ovariectomized group appeared partially filled by newly formed bone, with areas of interposed connective tissue. The statistical analysis revealed that bone neoformation was significantly greater in the sham-operated group (57.41% at 14 days and 68.35 at 28 days) in comparison with the ovariectomized group (40.82% at 14 days and 53.09 at 28 days) at the 5% level. Conclusion: The estrogen depletion caused by the ovariectomy hindered the healing process of autogenous block bone grafts placed in the mandibles of aged rats.en
dc.description.affiliationSão Paulo State Univ, Div Periodont, Dept Surg & Integrated Clin, UNESP, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Div Periodont, Dept Surg & Integrated Clin, UNESP, São Paulo, Brazil
dc.format.extent207-214
dc.identifierhttp://www.quintpub.com/journals/omi/abstract.php?article_id=3303#.Ui9mPcbks_Y
dc.identifier.citationInternational Journal of Oral & Maxillofacial Implants. Hanover Park: Quintessence Publishing Co Inc, v. 23, n. 2, p. 207-214, 2008.
dc.identifier.issn0882-2786
dc.identifier.lattes9831236034935598
dc.identifier.urihttp://hdl.handle.net/11449/15050
dc.identifier.wosWOS:000255439300003
dc.language.isoeng
dc.publisherQuintessence Publishing Co Inc
dc.relation.isnodouble240666*
dc.relation.isnodouble234699*
dc.relation.ispartofInternational Journal of Oral & Maxillofacial Implants
dc.relation.ispartofjcr1.699
dc.relation.ispartofsjr1,576
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectautograften
dc.subjectbone transplantationen
dc.subjectestrogen deficiencyen
dc.subjectmenopauseen
dc.subjectovariectomyen
dc.titleInfluence of ovariectomy on healing of autogenous bone block grafts in the mandible: A histomorphometric study in an aged rat modelen
dc.typeArtigo
dcterms.licensehttp://www.quintpub.com/journals/jop/orderreprints.php
dcterms.rightsHolderQuintessence Publishing Co Inc
unesp.author.lattes9831236034935598
unesp.author.orcid0000-0002-5995-5747[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Cirurgia e Clínica Integrada - FOA