Label free redox capacitive biosensing

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dc.contributor.authorFernandes, Flávio C. Bedatty [UNESP]
dc.contributor.authorGóes, Márcio S. [UNESP]
dc.contributor.authorDavis, Jason J.
dc.contributor.authorBueno, Paulo Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Oxford
dc.date.accessioned2014-05-27T11:30:53Z
dc.date.available2014-05-27T11:30:53Z
dc.date.issued2013-12-15
dc.description.abstractA surface confined redox group contributes to an interfacial charging (quantifiable by redox capacitance) that can be sensitively probed by impedance derived capacitance spectroscopy. In generating mixed molecular films comprising such redox groups, together with specific recognition elements (here antibodies), this charging signal is able to sensitively transduce the recognition and binding of specific analytes. This novel transduction method, exemplified here with C-reactive protein, an important biomarker of cardiac status and general trauma, is equally applicable to any suitably prepared interfacial combination of redox reporter and receptor. The assays are label free, ultrasensitive, highly specific and accompanied by a good linear range. © 2013 Elsevier B.V.en
dc.description.affiliationInstituto de Química Universidade Estadual Paulista, CP 355, 14800-900 Araraquara, São Paulo
dc.description.affiliationDepartment of Chemistry University of Oxford, South Parks Road, Oxford OX1 3QZ
dc.description.affiliationUnespInstituto de Química Universidade Estadual Paulista, CP 355, 14800-900 Araraquara, São Paulo
dc.format.extent437-440
dc.identifierhttp://dx.doi.org/10.1016/j.bios.2013.06.043
dc.identifier.citationBiosensors and Bioelectronics, v. 50, p. 437-440.
dc.identifier.doi10.1016/j.bios.2013.06.043
dc.identifier.issn0956-5663
dc.identifier.issn1873-4235
dc.identifier.lattes0477045906733254
dc.identifier.orcid0000-0003-2827-0208
dc.identifier.scopus2-s2.0-84880937473
dc.identifier.urihttp://hdl.handle.net/11449/76923
dc.identifier.wosWOS:000325188200068
dc.language.isoeng
dc.relation.ispartofBiosensors and Bioelectronics
dc.relation.ispartofjcr8.173
dc.relation.ispartofsjr2,373
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBiosensor
dc.subjectCapacitance spectroscopy
dc.subjectImmunosensors
dc.subjectRedox capacitance
dc.subjectC-reactive proteins
dc.subjectInterfacial charging
dc.subjectMolecular films
dc.subjectSpecific recognition
dc.subjectTransduction method
dc.subjectUltra sensitives
dc.subjectBiosensors
dc.subjectCapacitance
dc.subjectantibody
dc.subjectC reactive protein
dc.subjectbinding affinity
dc.subjectbiosensor
dc.subjectcapacitance spectroscopy
dc.subjectcontrolled study
dc.subjectelectric capacitance
dc.subjectelectrode
dc.subjectimmunosensor
dc.subjectmolecular recognition
dc.subjectoxidation reduction state
dc.subjectreproducibility
dc.subjectsensitivity and specificity
dc.subjectspectroscopy
dc.titleLabel free redox capacitive biosensingen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes0477045906733254[4]
unesp.author.orcid0000-0003-2827-0208[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.departmentFísico-Química - IQARpt

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